Update on Rifampin Drug Interactions II

Shawn M. Borcherding, Anne M. Baciewicz, Timothy H. Self

Research output: Contribution to journalArticle

80 Citations (Scopus)

Abstract

Rifampin is a potent inducer of hepatic P450 oxidative enzymes. Clinically important drug interactions have been documented between rifampin and numerous other drugs, such as oral anticoagulants, oral contraceptives, cyclosporine, digitalis, and ketoconazole. New, potentially clinically significant rifampin drug interactions have been reported for haloperidol, several antiarrhythmics, fluconazole, diltiazem, and select benzodiazepines. Further research has been conducted for previously reported drug interactions with rifampin involving such drugs as glucocorticoids, cyclosporine, verapamil, and oral anticoagulants. Proper management of these interactions is essential to avoid therapeutic failures on initiating rifampin therapy and potential toxic reactions after discontinuing rifampin. New rifampin drug interactions will continue to be identified with future investigations.

Original languageEnglish (US)
Pages (from-to)711-716
Number of pages6
JournalArchives of Internal Medicine
Volume152
Issue number4
DOIs
StatePublished - Jan 1 1992

Fingerprint

Rifampin
Drug Interactions
Anticoagulants
Cyclosporine
Ketoconazole
Digitalis
Diltiazem
Fluconazole
Poisons
Haloperidol
Oral Contraceptives
Verapamil
Benzodiazepines
Pharmaceutical Preparations
Cytochrome P-450 Enzyme System
Glucocorticoids
Liver
Therapeutics
Research

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Borcherding, S. M., Baciewicz, A. M., & Self, T. H. (1992). Update on Rifampin Drug Interactions II. Archives of Internal Medicine, 152(4), 711-716. https://doi.org/10.1001/archinte.1992.00400160029007

Update on Rifampin Drug Interactions II. / Borcherding, Shawn M.; Baciewicz, Anne M.; Self, Timothy H.

In: Archives of Internal Medicine, Vol. 152, No. 4, 01.01.1992, p. 711-716.

Research output: Contribution to journalArticle

Borcherding, SM, Baciewicz, AM & Self, TH 1992, 'Update on Rifampin Drug Interactions II', Archives of Internal Medicine, vol. 152, no. 4, pp. 711-716. https://doi.org/10.1001/archinte.1992.00400160029007
Borcherding, Shawn M. ; Baciewicz, Anne M. ; Self, Timothy H. / Update on Rifampin Drug Interactions II. In: Archives of Internal Medicine. 1992 ; Vol. 152, No. 4. pp. 711-716.
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