Update on rifampin drug interactions, III

Valerie A. Strayhorn, Anne M. Baciewicz, Timothy H. Self

Research output: Contribution to journalReview article

72 Citations (Scopus)

Abstract

Rifampin is a potent inducer of cytochrome P-450 oxidative enzymes. Examples of well-documented, clinically significant interactions include warfarin, oral contraceptives, cyclosporine, glucocorticoids, ketoconazole, theophylline, quinidine, digitoxin, and verapamil. Recent reports have demonstrated clinically relevant interactions with protease inhibitors, zidovudine, delavirdine, itraconazole, nifedipine, midazolam or triazolam, nortriptyline, and doxycycline. To avoid reduced therapeutic response, therapeutic failure, or toxic reactions when rifampin is added to or discontinued from medication regimens, clinicians need to be cognizant of these interactions. Enhanced knowledge of known interactions will continue to develop, including research on induction of specific cytochrome P-450 isoenzymes. New rifampin interactions will be discovered with further investigations.

Original languageEnglish (US)
Pages (from-to)2453-2458
Number of pages6
JournalArchives of Internal Medicine
Volume157
Issue number21
StatePublished - Dec 16 1997

Fingerprint

Rifampin
Drug Interactions
Delavirdine
Triazolam
Digitoxin
Nortriptyline
Ketoconazole
Itraconazole
Zidovudine
Doxycycline
Poisons
Midazolam
Warfarin
Nifedipine
Theophylline
Oral Contraceptives
Protease Inhibitors
Cytochrome P-450 Enzyme System
Cyclosporine
Glucocorticoids

All Science Journal Classification (ASJC) codes

  • Internal Medicine

Cite this

Strayhorn, V. A., Baciewicz, A. M., & Self, T. H. (1997). Update on rifampin drug interactions, III. Archives of Internal Medicine, 157(21), 2453-2458.

Update on rifampin drug interactions, III. / Strayhorn, Valerie A.; Baciewicz, Anne M.; Self, Timothy H.

In: Archives of Internal Medicine, Vol. 157, No. 21, 16.12.1997, p. 2453-2458.

Research output: Contribution to journalReview article

Strayhorn, VA, Baciewicz, AM & Self, TH 1997, 'Update on rifampin drug interactions, III', Archives of Internal Medicine, vol. 157, no. 21, pp. 2453-2458.
Strayhorn VA, Baciewicz AM, Self TH. Update on rifampin drug interactions, III. Archives of Internal Medicine. 1997 Dec 16;157(21):2453-2458.
Strayhorn, Valerie A. ; Baciewicz, Anne M. ; Self, Timothy H. / Update on rifampin drug interactions, III. In: Archives of Internal Medicine. 1997 ; Vol. 157, No. 21. pp. 2453-2458.
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