Upper urinary tract urothelial carcinoma pathology

Kiril Trpkov, Steven Christopher Smith, Premal Patel, Mahul Amin

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)

Abstract

Urothelial carcinomas of the upper tract are malignant neoplasms arising from the pelvicalyceal and ureteral mucosal lining and sharing the same pathologic spectrum and overall classification as urothelial neoplasms of the urinary bladder. However, upper tract urothelial carcinomas are more frequently high grade and high stage and show frequent variant differentiation. The histologic differential diagnosis of upper tract urothelial carcinoma, when it involves the kidney, includes collecting duct carcinoma, high-grade renal cell carcinoma, and metastasis, for which contemporary immunohistochemical panels may complement integration of gross, histomorphological, clinical, and radiographic assessment. Grossly, these lesions appear as papillary, polypoid, ulcerative, or infi ltrative masses, with thickening of the ureteral or the renal pelvic wall. Careful gross examination and comprehensive sampling of the tumor in this region are essential to reliably distinguish a noninvasive from an invasive tumor, as well as to assign appropriate stage to invasive cases, given the paramount importance of pathologic stage to prognosis. Recently, a growing body of data implicates similar molecular pathways in the genesis of upper tract urothelial carcinoma to those in the genesis of urothelial carcinomas of the lower tract. Evaluation of these markers as diagnostic, predictive, and prognostic biomarkers is ongoing.

Original languageEnglish (US)
Title of host publicationUpper Tract Urothelial Carcinoma
PublisherSpringer New York
Pages45-89
Number of pages45
ISBN (Electronic)9781493915019
ISBN (Print)9781493915002
DOIs
StatePublished - Jan 1 2015
Externally publishedYes

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Urinary Tract
Pathology
Carcinoma
Renal Cell Carcinoma
Neoplasms
Urinary Bladder Neoplasms
Differential Diagnosis
Biomarkers
Neoplasm Metastasis
Kidney

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Trpkov, K., Smith, S. C., Patel, P., & Amin, M. (2015). Upper urinary tract urothelial carcinoma pathology. In Upper Tract Urothelial Carcinoma (pp. 45-89). Springer New York. https://doi.org/10.1007/978-1-4939-1501-9_3

Upper urinary tract urothelial carcinoma pathology. / Trpkov, Kiril; Smith, Steven Christopher; Patel, Premal; Amin, Mahul.

Upper Tract Urothelial Carcinoma. Springer New York, 2015. p. 45-89.

Research output: Chapter in Book/Report/Conference proceedingChapter

Trpkov, K, Smith, SC, Patel, P & Amin, M 2015, Upper urinary tract urothelial carcinoma pathology. in Upper Tract Urothelial Carcinoma. Springer New York, pp. 45-89. https://doi.org/10.1007/978-1-4939-1501-9_3
Trpkov K, Smith SC, Patel P, Amin M. Upper urinary tract urothelial carcinoma pathology. In Upper Tract Urothelial Carcinoma. Springer New York. 2015. p. 45-89 https://doi.org/10.1007/978-1-4939-1501-9_3
Trpkov, Kiril ; Smith, Steven Christopher ; Patel, Premal ; Amin, Mahul. / Upper urinary tract urothelial carcinoma pathology. Upper Tract Urothelial Carcinoma. Springer New York, 2015. pp. 45-89
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