Uptake of a colorectal cancer screening blood test is higher than of a fecal test offered in clinic

A randomized trial

Elizabeth G. Liles, Gloria D. Coronado, Nancy Perrin, Amy Howell Harte, Raymond Nungesser, Neil Quigley, Nicholas Potter, Gunter Weiss, Thomas Koenig, Theo deVos

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Introduction Colorectal cancer screening programs seek to maintain patient adherence to repeated tests over the duration of patients’ screening eligibility. This study compares uptake of an experimental blood test with that of a FIT for colorectal cancer screening in an office setting. Methods This small two-site randomized controlled trial (ClinicalTrials.gov, ID NCT02251782) assigned 413 average-risk adults overdue for screening in an integrated health system to one of two arms: Offer of a FIT versus offer of a blood test for colorectal cancer screening. The primary outcome was completion of the offered test within six weeks. Secondary outcomes were the proportion of participants with positive test results, and the proportion of participants with positive results who completed colonoscopy within 3 months of referral. Results 99.5% (CI95: 97.3%-100%) of participants in the blood test arm and 88.1% (CI95: 83.0% − 91.8%) of participants in the FIT arm completed the offered test, a difference of 11.4% (CI95: 6.9% − 15.9%, p<.001). 16.5% of participants in the blood test arm and 1.7% of participants in the FIT arm had a positive test. 20 of 30 and 2 of 3 in the blood test and FIT arms, respectively, either scheduled or completed a colonoscopy within 3 months of the positive test result. Conclusions Uptake of a blood test was higher than that of a FIT among participants in a randomized controlled trial. A blood test may be a useful option for those hesitant to screen with currently available tests.

Original languageEnglish (US)
Pages (from-to)27-31
Number of pages5
JournalCancer Treatment and Research Communications
Volume10
DOIs
StatePublished - Jan 1 2017
Externally publishedYes

Fingerprint

Hematologic Tests
Early Detection of Cancer
Colorectal Neoplasms
Colonoscopy
Randomized Controlled Trials
Patient Compliance
Referral and Consultation
Health

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Uptake of a colorectal cancer screening blood test is higher than of a fecal test offered in clinic : A randomized trial. / Liles, Elizabeth G.; Coronado, Gloria D.; Perrin, Nancy; Harte, Amy Howell; Nungesser, Raymond; Quigley, Neil; Potter, Nicholas; Weiss, Gunter; Koenig, Thomas; deVos, Theo.

In: Cancer Treatment and Research Communications, Vol. 10, 01.01.2017, p. 27-31.

Research output: Contribution to journalArticle

Liles, Elizabeth G. ; Coronado, Gloria D. ; Perrin, Nancy ; Harte, Amy Howell ; Nungesser, Raymond ; Quigley, Neil ; Potter, Nicholas ; Weiss, Gunter ; Koenig, Thomas ; deVos, Theo. / Uptake of a colorectal cancer screening blood test is higher than of a fecal test offered in clinic : A randomized trial. In: Cancer Treatment and Research Communications. 2017 ; Vol. 10. pp. 27-31.
@article{bdd42030f243499389e87e1182ad2b71,
title = "Uptake of a colorectal cancer screening blood test is higher than of a fecal test offered in clinic: A randomized trial",
abstract = "Introduction Colorectal cancer screening programs seek to maintain patient adherence to repeated tests over the duration of patients’ screening eligibility. This study compares uptake of an experimental blood test with that of a FIT for colorectal cancer screening in an office setting. Methods This small two-site randomized controlled trial (ClinicalTrials.gov, ID NCT02251782) assigned 413 average-risk adults overdue for screening in an integrated health system to one of two arms: Offer of a FIT versus offer of a blood test for colorectal cancer screening. The primary outcome was completion of the offered test within six weeks. Secondary outcomes were the proportion of participants with positive test results, and the proportion of participants with positive results who completed colonoscopy within 3 months of referral. Results 99.5{\%} (CI95: 97.3{\%}-100{\%}) of participants in the blood test arm and 88.1{\%} (CI95: 83.0{\%} − 91.8{\%}) of participants in the FIT arm completed the offered test, a difference of 11.4{\%} (CI95: 6.9{\%} − 15.9{\%}, p<.001). 16.5{\%} of participants in the blood test arm and 1.7{\%} of participants in the FIT arm had a positive test. 20 of 30 and 2 of 3 in the blood test and FIT arms, respectively, either scheduled or completed a colonoscopy within 3 months of the positive test result. Conclusions Uptake of a blood test was higher than that of a FIT among participants in a randomized controlled trial. A blood test may be a useful option for those hesitant to screen with currently available tests.",
author = "Liles, {Elizabeth G.} and Coronado, {Gloria D.} and Nancy Perrin and Harte, {Amy Howell} and Raymond Nungesser and Neil Quigley and Nicholas Potter and Gunter Weiss and Thomas Koenig and Theo deVos",
year = "2017",
month = "1",
day = "1",
doi = "10.1016/j.ctarc.2016.12.004",
language = "English (US)",
volume = "10",
pages = "27--31",
journal = "Cancer Treatment and Research Communications",
issn = "2213-0896",
publisher = "Elsevier Ltd",

}

TY - JOUR

T1 - Uptake of a colorectal cancer screening blood test is higher than of a fecal test offered in clinic

T2 - A randomized trial

AU - Liles, Elizabeth G.

AU - Coronado, Gloria D.

AU - Perrin, Nancy

AU - Harte, Amy Howell

AU - Nungesser, Raymond

AU - Quigley, Neil

AU - Potter, Nicholas

AU - Weiss, Gunter

AU - Koenig, Thomas

AU - deVos, Theo

PY - 2017/1/1

Y1 - 2017/1/1

N2 - Introduction Colorectal cancer screening programs seek to maintain patient adherence to repeated tests over the duration of patients’ screening eligibility. This study compares uptake of an experimental blood test with that of a FIT for colorectal cancer screening in an office setting. Methods This small two-site randomized controlled trial (ClinicalTrials.gov, ID NCT02251782) assigned 413 average-risk adults overdue for screening in an integrated health system to one of two arms: Offer of a FIT versus offer of a blood test for colorectal cancer screening. The primary outcome was completion of the offered test within six weeks. Secondary outcomes were the proportion of participants with positive test results, and the proportion of participants with positive results who completed colonoscopy within 3 months of referral. Results 99.5% (CI95: 97.3%-100%) of participants in the blood test arm and 88.1% (CI95: 83.0% − 91.8%) of participants in the FIT arm completed the offered test, a difference of 11.4% (CI95: 6.9% − 15.9%, p<.001). 16.5% of participants in the blood test arm and 1.7% of participants in the FIT arm had a positive test. 20 of 30 and 2 of 3 in the blood test and FIT arms, respectively, either scheduled or completed a colonoscopy within 3 months of the positive test result. Conclusions Uptake of a blood test was higher than that of a FIT among participants in a randomized controlled trial. A blood test may be a useful option for those hesitant to screen with currently available tests.

AB - Introduction Colorectal cancer screening programs seek to maintain patient adherence to repeated tests over the duration of patients’ screening eligibility. This study compares uptake of an experimental blood test with that of a FIT for colorectal cancer screening in an office setting. Methods This small two-site randomized controlled trial (ClinicalTrials.gov, ID NCT02251782) assigned 413 average-risk adults overdue for screening in an integrated health system to one of two arms: Offer of a FIT versus offer of a blood test for colorectal cancer screening. The primary outcome was completion of the offered test within six weeks. Secondary outcomes were the proportion of participants with positive test results, and the proportion of participants with positive results who completed colonoscopy within 3 months of referral. Results 99.5% (CI95: 97.3%-100%) of participants in the blood test arm and 88.1% (CI95: 83.0% − 91.8%) of participants in the FIT arm completed the offered test, a difference of 11.4% (CI95: 6.9% − 15.9%, p<.001). 16.5% of participants in the blood test arm and 1.7% of participants in the FIT arm had a positive test. 20 of 30 and 2 of 3 in the blood test and FIT arms, respectively, either scheduled or completed a colonoscopy within 3 months of the positive test result. Conclusions Uptake of a blood test was higher than that of a FIT among participants in a randomized controlled trial. A blood test may be a useful option for those hesitant to screen with currently available tests.

UR - http://www.scopus.com/inward/record.url?scp=85034047503&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034047503&partnerID=8YFLogxK

U2 - 10.1016/j.ctarc.2016.12.004

DO - 10.1016/j.ctarc.2016.12.004

M3 - Article

VL - 10

SP - 27

EP - 31

JO - Cancer Treatment and Research Communications

JF - Cancer Treatment and Research Communications

SN - 2213-0896

ER -