Ureaplasma in lung

2. Association with bronchopulmonary dysplasia in premature newborns

Barbara Dubray-Benstein, Dennis T. Crouse, D. Radford Shanklin, Donald D. Ourth

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Infants with Ureaplasma urealyticum in the lower respiratory tract are at risk for chronic lung disease (CLD) or bronchopulmonary dysplasia (BPD) but causality has been difficult to prove. The goal of this study was to identify ureaplasma in human neonatal lung tissue using the in situ hybridization (ISH) procedure described in Part 1 (Exp. Mol. Pathol., in press) of this report. By correlating their presence with the histopathologic findings, it may be possible to provide further evidence of the pathogenicity of ureaplasmas and their association with BPD. Lung autopsy tissue from seven infants with positive cultures and seven infants with negative cultures for ureaplasma were included in the study. All culture-positive infants were positive for ureaplasma on ISH and all had histopathologic evidence of BPD. Two of the seven infants with negative cultures were positive for ureaplasma with ISH. Of interest, these two infants were also found to have BPD at autopsy. The other five infants with negative cultures were also negative for ureaplasma on ISH and had no evidence of BPD. This study correlates the presence of U. urealyticum by ISH with the finding of BPD on histopathologic evaluation and provides evidence that it has a role in the development of CLD.

Original languageEnglish (US)
Pages (from-to)171-177
Number of pages7
JournalExperimental and Molecular Pathology
Volume75
Issue number2
DOIs
StatePublished - Jan 1 2003

Fingerprint

Ureaplasma
Bronchopulmonary Dysplasia
Pulmonary diseases
Newborn Infant
Tissue
In Situ Hybridization
Lung
Ureaplasma urealyticum
Lung Diseases
Autopsy
Chronic Disease
Causality
Respiratory System
Virulence

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Molecular Biology
  • Clinical Biochemistry

Cite this

Ureaplasma in lung : 2. Association with bronchopulmonary dysplasia in premature newborns. / Dubray-Benstein, Barbara; Crouse, Dennis T.; Shanklin, D. Radford; Ourth, Donald D.

In: Experimental and Molecular Pathology, Vol. 75, No. 2, 01.01.2003, p. 171-177.

Research output: Contribution to journalArticle

Dubray-Benstein, Barbara ; Crouse, Dennis T. ; Shanklin, D. Radford ; Ourth, Donald D. / Ureaplasma in lung : 2. Association with bronchopulmonary dysplasia in premature newborns. In: Experimental and Molecular Pathology. 2003 ; Vol. 75, No. 2. pp. 171-177.
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