Ureteral replacement using ileum in compromised renal function

W Waters, G. Herbster, V. R. Jablokow, D. J. Reda

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Ureteral replacement by ileum is an accepted technique in a highly selective patient population. Two major contraindications in using an ileal ureter are compromised renal function (serum creatinine > 2) and a functionally abnormal bladder. We used ileum to bridge a ureteral defect in animals with half of a solitary kidney an low grade azotemia to see if the antirefluxing mechanism of the lower ureter prevented further deterioration in renal function. Twelve female mongrel dogs underwent a right nephrectomy, followed by a left partial nephrectomy six weeks later. Group I (six dogs) had a six cm. segment of ileum interposed between the upper and lower ureteral segments (nonrefluxing). Group II (five dogs) had a ten cm. segment of ileum placed from the upper third of the ureter to the bladder (refluxing). Cystograms, intravenous pyelograms, serum electrocytes, BUN and creatinine were obtained preoperatively, six weeks after the right nephrectomy, one month after left partial nephrectomy and six months after ileal replacement prior to sacrifice. The BUN and creatinine deteriorated in Group II compared to Group I, p = .02 and p = 0.4 respectively (Mann-Whitney test). The BUN and creatinine also deteriorated between one month after left partial nephrectomy and six months after ileal replacement within Group II, p = .07 and p = .14, respectively (Wilcoxon matched-pairs test) but not in Group I. These data suggest that the antirefluxing mechanism of the lower ureter might prevent further deterioration in renal function. We feel that ileum can be used with caution, as an interposition in compromised in renal function.

Original languageEnglish (US)
Pages (from-to)432-436
Number of pages5
JournalJournal of Urology
Volume141
Issue number2
StatePublished - Jan 1 1989
Externally publishedYes

Fingerprint

Nephrectomy
Ileum
Ureter
Blood Urea Nitrogen
Creatinine
Kidney
Dogs
Urinary Bladder
Azotemia
Urography
Serum
Population

All Science Journal Classification (ASJC) codes

  • Urology

Cite this

Waters, W., Herbster, G., Jablokow, V. R., & Reda, D. J. (1989). Ureteral replacement using ileum in compromised renal function. Journal of Urology, 141(2), 432-436.

Ureteral replacement using ileum in compromised renal function. / Waters, W; Herbster, G.; Jablokow, V. R.; Reda, D. J.

In: Journal of Urology, Vol. 141, No. 2, 01.01.1989, p. 432-436.

Research output: Contribution to journalArticle

Waters, W, Herbster, G, Jablokow, VR & Reda, DJ 1989, 'Ureteral replacement using ileum in compromised renal function', Journal of Urology, vol. 141, no. 2, pp. 432-436.
Waters W, Herbster G, Jablokow VR, Reda DJ. Ureteral replacement using ileum in compromised renal function. Journal of Urology. 1989 Jan 1;141(2):432-436.
Waters, W ; Herbster, G. ; Jablokow, V. R. ; Reda, D. J. / Ureteral replacement using ileum in compromised renal function. In: Journal of Urology. 1989 ; Vol. 141, No. 2. pp. 432-436.
@article{41b724d0e2b2492eb968ba783612a2e2,
title = "Ureteral replacement using ileum in compromised renal function",
abstract = "Ureteral replacement by ileum is an accepted technique in a highly selective patient population. Two major contraindications in using an ileal ureter are compromised renal function (serum creatinine > 2) and a functionally abnormal bladder. We used ileum to bridge a ureteral defect in animals with half of a solitary kidney an low grade azotemia to see if the antirefluxing mechanism of the lower ureter prevented further deterioration in renal function. Twelve female mongrel dogs underwent a right nephrectomy, followed by a left partial nephrectomy six weeks later. Group I (six dogs) had a six cm. segment of ileum interposed between the upper and lower ureteral segments (nonrefluxing). Group II (five dogs) had a ten cm. segment of ileum placed from the upper third of the ureter to the bladder (refluxing). Cystograms, intravenous pyelograms, serum electrocytes, BUN and creatinine were obtained preoperatively, six weeks after the right nephrectomy, one month after left partial nephrectomy and six months after ileal replacement prior to sacrifice. The BUN and creatinine deteriorated in Group II compared to Group I, p = .02 and p = 0.4 respectively (Mann-Whitney test). The BUN and creatinine also deteriorated between one month after left partial nephrectomy and six months after ileal replacement within Group II, p = .07 and p = .14, respectively (Wilcoxon matched-pairs test) but not in Group I. These data suggest that the antirefluxing mechanism of the lower ureter might prevent further deterioration in renal function. We feel that ileum can be used with caution, as an interposition in compromised in renal function.",
author = "W Waters and G. Herbster and Jablokow, {V. R.} and Reda, {D. J.}",
year = "1989",
month = "1",
day = "1",
language = "English (US)",
volume = "141",
pages = "432--436",
journal = "Journal of Urology",
issn = "0022-5347",
publisher = "Elsevier Inc.",
number = "2",

}

TY - JOUR

T1 - Ureteral replacement using ileum in compromised renal function

AU - Waters, W

AU - Herbster, G.

AU - Jablokow, V. R.

AU - Reda, D. J.

PY - 1989/1/1

Y1 - 1989/1/1

N2 - Ureteral replacement by ileum is an accepted technique in a highly selective patient population. Two major contraindications in using an ileal ureter are compromised renal function (serum creatinine > 2) and a functionally abnormal bladder. We used ileum to bridge a ureteral defect in animals with half of a solitary kidney an low grade azotemia to see if the antirefluxing mechanism of the lower ureter prevented further deterioration in renal function. Twelve female mongrel dogs underwent a right nephrectomy, followed by a left partial nephrectomy six weeks later. Group I (six dogs) had a six cm. segment of ileum interposed between the upper and lower ureteral segments (nonrefluxing). Group II (five dogs) had a ten cm. segment of ileum placed from the upper third of the ureter to the bladder (refluxing). Cystograms, intravenous pyelograms, serum electrocytes, BUN and creatinine were obtained preoperatively, six weeks after the right nephrectomy, one month after left partial nephrectomy and six months after ileal replacement prior to sacrifice. The BUN and creatinine deteriorated in Group II compared to Group I, p = .02 and p = 0.4 respectively (Mann-Whitney test). The BUN and creatinine also deteriorated between one month after left partial nephrectomy and six months after ileal replacement within Group II, p = .07 and p = .14, respectively (Wilcoxon matched-pairs test) but not in Group I. These data suggest that the antirefluxing mechanism of the lower ureter might prevent further deterioration in renal function. We feel that ileum can be used with caution, as an interposition in compromised in renal function.

AB - Ureteral replacement by ileum is an accepted technique in a highly selective patient population. Two major contraindications in using an ileal ureter are compromised renal function (serum creatinine > 2) and a functionally abnormal bladder. We used ileum to bridge a ureteral defect in animals with half of a solitary kidney an low grade azotemia to see if the antirefluxing mechanism of the lower ureter prevented further deterioration in renal function. Twelve female mongrel dogs underwent a right nephrectomy, followed by a left partial nephrectomy six weeks later. Group I (six dogs) had a six cm. segment of ileum interposed between the upper and lower ureteral segments (nonrefluxing). Group II (five dogs) had a ten cm. segment of ileum placed from the upper third of the ureter to the bladder (refluxing). Cystograms, intravenous pyelograms, serum electrocytes, BUN and creatinine were obtained preoperatively, six weeks after the right nephrectomy, one month after left partial nephrectomy and six months after ileal replacement prior to sacrifice. The BUN and creatinine deteriorated in Group II compared to Group I, p = .02 and p = 0.4 respectively (Mann-Whitney test). The BUN and creatinine also deteriorated between one month after left partial nephrectomy and six months after ileal replacement within Group II, p = .07 and p = .14, respectively (Wilcoxon matched-pairs test) but not in Group I. These data suggest that the antirefluxing mechanism of the lower ureter might prevent further deterioration in renal function. We feel that ileum can be used with caution, as an interposition in compromised in renal function.

UR - http://www.scopus.com/inward/record.url?scp=0024515217&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0024515217&partnerID=8YFLogxK

M3 - Article

VL - 141

SP - 432

EP - 436

JO - Journal of Urology

JF - Journal of Urology

SN - 0022-5347

IS - 2

ER -