Uric Acid Level and Erectile Dysfunction in Patients with Coronary Artery Disease

Yalcin Solak, Hakan Akilli, Mehmet Kayrak, Alpay Aribas, Abduzhappar Gaipov, Suleyman Turk, Santos E. Perez-Pozo, Adrian Covic, Kim Mcfann, Richard J. Johnson, Mehmet Kanbay

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Introduction: Erectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD). Aim: This study aims to evaluate the association of serum uric acid levels with presence and severity of ED in patients presenting with chest pain of presumed cardiac origin. Methods: This is a cross-sectional study of 312 adult male patients with suspected CAD who underwent exercise stress test (EST) for workup of chest pain and completed a sexual health inventory for men survey form to determine the presence and severity of ED. Routine serum biochemistry (and uric acid levels) were measured. Logistic regression analysis was used to assess risk factors for ED. Main Outcome Measures: The short version of the International Index of Erectile Function questionnaire diagnosed ED (cutoff score≤21). Serum uric acid levels were determined. Patients with chest pain of suspected cardiac origin underwent an EST. Results: One hundred forty-nine of 312 (47.7%) male subjects had ED by survey criteria. Patients with ED were older and had more frequent CAD, hypertension, diabetes and impaired renal function, and also had significantly higher levels of uric acid, fibrinogen, glucose, C-reactive protein, triglycerides compared with patients without ED. Uric acid levels were associated with ED by univariate analysis (odds ratio=1.36, P=0.002); however, this association was not observed in multivariate analysis adjusted for estimated glomerular filtration rate. Conclusion: Subjects presenting with chest pain of presumed cardiac origin are more likely to have ED if they have elevated uric acid levels.

Original languageEnglish (US)
Pages (from-to)165-172
Number of pages8
JournalJournal of Sexual Medicine
Volume11
Issue number1
DOIs
StatePublished - Jan 1 2014

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Erectile Dysfunction
Uric Acid
Coronary Artery Disease
Chest Pain
Exercise Test
Serum
Cardiovascular Diseases
Reproductive Health
Glomerular Filtration Rate
Biochemistry
C-Reactive Protein
Fibrinogen
Triglycerides
Oxidative Stress
Multivariate Analysis
Cross-Sectional Studies
Logistic Models
Odds Ratio
Regression Analysis
Outcome Assessment (Health Care)

All Science Journal Classification (ASJC) codes

  • Reproductive Medicine
  • Obstetrics and Gynecology
  • Urology

Cite this

Uric Acid Level and Erectile Dysfunction in Patients with Coronary Artery Disease. / Solak, Yalcin; Akilli, Hakan; Kayrak, Mehmet; Aribas, Alpay; Gaipov, Abduzhappar; Turk, Suleyman; Perez-Pozo, Santos E.; Covic, Adrian; Mcfann, Kim; Johnson, Richard J.; Kanbay, Mehmet.

In: Journal of Sexual Medicine, Vol. 11, No. 1, 01.01.2014, p. 165-172.

Research output: Contribution to journalArticle

Solak, Y, Akilli, H, Kayrak, M, Aribas, A, Gaipov, A, Turk, S, Perez-Pozo, SE, Covic, A, Mcfann, K, Johnson, RJ & Kanbay, M 2014, 'Uric Acid Level and Erectile Dysfunction in Patients with Coronary Artery Disease', Journal of Sexual Medicine, vol. 11, no. 1, pp. 165-172. https://doi.org/10.1111/jsm.12332
Solak, Yalcin ; Akilli, Hakan ; Kayrak, Mehmet ; Aribas, Alpay ; Gaipov, Abduzhappar ; Turk, Suleyman ; Perez-Pozo, Santos E. ; Covic, Adrian ; Mcfann, Kim ; Johnson, Richard J. ; Kanbay, Mehmet. / Uric Acid Level and Erectile Dysfunction in Patients with Coronary Artery Disease. In: Journal of Sexual Medicine. 2014 ; Vol. 11, No. 1. pp. 165-172.
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abstract = "Introduction: Erectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD). Aim: This study aims to evaluate the association of serum uric acid levels with presence and severity of ED in patients presenting with chest pain of presumed cardiac origin. Methods: This is a cross-sectional study of 312 adult male patients with suspected CAD who underwent exercise stress test (EST) for workup of chest pain and completed a sexual health inventory for men survey form to determine the presence and severity of ED. Routine serum biochemistry (and uric acid levels) were measured. Logistic regression analysis was used to assess risk factors for ED. Main Outcome Measures: The short version of the International Index of Erectile Function questionnaire diagnosed ED (cutoff score≤21). Serum uric acid levels were determined. Patients with chest pain of suspected cardiac origin underwent an EST. Results: One hundred forty-nine of 312 (47.7{\%}) male subjects had ED by survey criteria. Patients with ED were older and had more frequent CAD, hypertension, diabetes and impaired renal function, and also had significantly higher levels of uric acid, fibrinogen, glucose, C-reactive protein, triglycerides compared with patients without ED. Uric acid levels were associated with ED by univariate analysis (odds ratio=1.36, P=0.002); however, this association was not observed in multivariate analysis adjusted for estimated glomerular filtration rate. Conclusion: Subjects presenting with chest pain of presumed cardiac origin are more likely to have ED if they have elevated uric acid levels.",
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AU - Solak, Yalcin

AU - Akilli, Hakan

AU - Kayrak, Mehmet

AU - Aribas, Alpay

AU - Gaipov, Abduzhappar

AU - Turk, Suleyman

AU - Perez-Pozo, Santos E.

AU - Covic, Adrian

AU - Mcfann, Kim

AU - Johnson, Richard J.

AU - Kanbay, Mehmet

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N2 - Introduction: Erectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD). Aim: This study aims to evaluate the association of serum uric acid levels with presence and severity of ED in patients presenting with chest pain of presumed cardiac origin. Methods: This is a cross-sectional study of 312 adult male patients with suspected CAD who underwent exercise stress test (EST) for workup of chest pain and completed a sexual health inventory for men survey form to determine the presence and severity of ED. Routine serum biochemistry (and uric acid levels) were measured. Logistic regression analysis was used to assess risk factors for ED. Main Outcome Measures: The short version of the International Index of Erectile Function questionnaire diagnosed ED (cutoff score≤21). Serum uric acid levels were determined. Patients with chest pain of suspected cardiac origin underwent an EST. Results: One hundred forty-nine of 312 (47.7%) male subjects had ED by survey criteria. Patients with ED were older and had more frequent CAD, hypertension, diabetes and impaired renal function, and also had significantly higher levels of uric acid, fibrinogen, glucose, C-reactive protein, triglycerides compared with patients without ED. Uric acid levels were associated with ED by univariate analysis (odds ratio=1.36, P=0.002); however, this association was not observed in multivariate analysis adjusted for estimated glomerular filtration rate. Conclusion: Subjects presenting with chest pain of presumed cardiac origin are more likely to have ED if they have elevated uric acid levels.

AB - Introduction: Erectile dysfunction (ED) is a frequent complaint of elderly subjects and is closely associated with endothelial dysfunction and cardiovascular disease (CVD). Uric acid is also associated with endothelial dysfunction, oxidative stress, and CVD, raising the hypothesis that an increased serum uric acid might predict ED in patients who are at risk for coronary artery disease (CAD). Aim: This study aims to evaluate the association of serum uric acid levels with presence and severity of ED in patients presenting with chest pain of presumed cardiac origin. Methods: This is a cross-sectional study of 312 adult male patients with suspected CAD who underwent exercise stress test (EST) for workup of chest pain and completed a sexual health inventory for men survey form to determine the presence and severity of ED. Routine serum biochemistry (and uric acid levels) were measured. Logistic regression analysis was used to assess risk factors for ED. Main Outcome Measures: The short version of the International Index of Erectile Function questionnaire diagnosed ED (cutoff score≤21). Serum uric acid levels were determined. Patients with chest pain of suspected cardiac origin underwent an EST. Results: One hundred forty-nine of 312 (47.7%) male subjects had ED by survey criteria. Patients with ED were older and had more frequent CAD, hypertension, diabetes and impaired renal function, and also had significantly higher levels of uric acid, fibrinogen, glucose, C-reactive protein, triglycerides compared with patients without ED. Uric acid levels were associated with ED by univariate analysis (odds ratio=1.36, P=0.002); however, this association was not observed in multivariate analysis adjusted for estimated glomerular filtration rate. Conclusion: Subjects presenting with chest pain of presumed cardiac origin are more likely to have ED if they have elevated uric acid levels.

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