Urinary thromboxane excretion in cardiac allograft rejection in immunosuppressed rats

Akira Kawaguchi, Mitchell Goldman, Ron Shapiro, Marie L. Foegh, Peter W. Ramwell, Richard R. Lower

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

Increased urinary excretion of immunoreactive thromboxane B2 (iTxB2) was found to have a high predictive value, with high sensitivity as an indicator of cardiac allograft rejection in both the immunosup-pressed and nonimmunosuppressed rat. In the animals receiving an allograft, urinary iTxB2 excretion significantly increased prior to the onset of rejection, remained elevated, and returned to basal values following completion of the episode. Urinary iTxB2 remained at baseline values in the control animals. The association between rejection and iTxB2 excretion was preserved regardless of the presence or nature of immunosuppression. Urinary iTxB2 excretion increased significantly prior to the reduction of graft beat or histological evidence of rejection. Evaluation of urinary iTxB2 monitoring as a noninvasive indicator for surveillance of clinical cardiac allograft rejection appears to be warranted.

Original languageEnglish (US)
Pages (from-to)346-350
Number of pages5
JournalTransplantation
Volume43
Issue number3
StatePublished - Jan 1 1987
Externally publishedYes

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Thromboxane B2
Thromboxanes
Allografts
Immunosuppression
Transplants

All Science Journal Classification (ASJC) codes

  • Transplantation

Cite this

Kawaguchi, A., Goldman, M., Shapiro, R., Foegh, M. L., Ramwell, P. W., & Lower, R. R. (1987). Urinary thromboxane excretion in cardiac allograft rejection in immunosuppressed rats. Transplantation, 43(3), 346-350.

Urinary thromboxane excretion in cardiac allograft rejection in immunosuppressed rats. / Kawaguchi, Akira; Goldman, Mitchell; Shapiro, Ron; Foegh, Marie L.; Ramwell, Peter W.; Lower, Richard R.

In: Transplantation, Vol. 43, No. 3, 01.01.1987, p. 346-350.

Research output: Contribution to journalArticle

Kawaguchi, A, Goldman, M, Shapiro, R, Foegh, ML, Ramwell, PW & Lower, RR 1987, 'Urinary thromboxane excretion in cardiac allograft rejection in immunosuppressed rats', Transplantation, vol. 43, no. 3, pp. 346-350.
Kawaguchi A, Goldman M, Shapiro R, Foegh ML, Ramwell PW, Lower RR. Urinary thromboxane excretion in cardiac allograft rejection in immunosuppressed rats. Transplantation. 1987 Jan 1;43(3):346-350.
Kawaguchi, Akira ; Goldman, Mitchell ; Shapiro, Ron ; Foegh, Marie L. ; Ramwell, Peter W. ; Lower, Richard R. / Urinary thromboxane excretion in cardiac allograft rejection in immunosuppressed rats. In: Transplantation. 1987 ; Vol. 43, No. 3. pp. 346-350.
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