Use of CB hamsters in the study of Treponema pertenue

R. F. Schell, J. L. Le Frock, Jegdish Babu, J. K. Chan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The CB/Ss LAK strain of inbred hamster was used as a model for studies of infection with Treponema pertenue and of acquired resistance to it. When infected, this strain developed cutaneous lesions which lasted for six to seven months, even in the presence of peak titres of antitreponemal antibody. The rate of appearance and resolution of these lesions varied with the size of the inoculum. The infected hamsters' inguinal lymph nodes increased significantly in weight and teemed with treponemes for several weeks. Animals infected for eight or 10 weeks obtained quick resolution of their lesions by treatment with penicillin and were thereafter resistant to reinfection.

Original languageEnglish (US)
Pages (from-to)316-319
Number of pages4
JournalBritish Journal of Venereal Diseases
Volume55
Issue number5
StatePublished - 1979
Externally publishedYes

Fingerprint

Treponema
Cricetinae
Groin
Penicillins
Lymph Nodes
Weights and Measures
Skin
Antibodies
Infection

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Urology

Cite this

Schell, R. F., Le Frock, J. L., Babu, J., & Chan, J. K. (1979). Use of CB hamsters in the study of Treponema pertenue. British Journal of Venereal Diseases, 55(5), 316-319.

Use of CB hamsters in the study of Treponema pertenue. / Schell, R. F.; Le Frock, J. L.; Babu, Jegdish; Chan, J. K.

In: British Journal of Venereal Diseases, Vol. 55, No. 5, 1979, p. 316-319.

Research output: Contribution to journalArticle

Schell, RF, Le Frock, JL, Babu, J & Chan, JK 1979, 'Use of CB hamsters in the study of Treponema pertenue', British Journal of Venereal Diseases, vol. 55, no. 5, pp. 316-319.
Schell, R. F. ; Le Frock, J. L. ; Babu, Jegdish ; Chan, J. K. / Use of CB hamsters in the study of Treponema pertenue. In: British Journal of Venereal Diseases. 1979 ; Vol. 55, No. 5. pp. 316-319.
@article{4ec4930d85294ec98698b8c70b330d1c,
title = "Use of CB hamsters in the study of Treponema pertenue",
abstract = "The CB/Ss LAK strain of inbred hamster was used as a model for studies of infection with Treponema pertenue and of acquired resistance to it. When infected, this strain developed cutaneous lesions which lasted for six to seven months, even in the presence of peak titres of antitreponemal antibody. The rate of appearance and resolution of these lesions varied with the size of the inoculum. The infected hamsters' inguinal lymph nodes increased significantly in weight and teemed with treponemes for several weeks. Animals infected for eight or 10 weeks obtained quick resolution of their lesions by treatment with penicillin and were thereafter resistant to reinfection.",
author = "Schell, {R. F.} and {Le Frock}, {J. L.} and Jegdish Babu and Chan, {J. K.}",
year = "1979",
language = "English (US)",
volume = "55",
pages = "316--319",
journal = "Sexually Transmitted Infections",
issn = "1368-4973",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - Use of CB hamsters in the study of Treponema pertenue

AU - Schell, R. F.

AU - Le Frock, J. L.

AU - Babu, Jegdish

AU - Chan, J. K.

PY - 1979

Y1 - 1979

N2 - The CB/Ss LAK strain of inbred hamster was used as a model for studies of infection with Treponema pertenue and of acquired resistance to it. When infected, this strain developed cutaneous lesions which lasted for six to seven months, even in the presence of peak titres of antitreponemal antibody. The rate of appearance and resolution of these lesions varied with the size of the inoculum. The infected hamsters' inguinal lymph nodes increased significantly in weight and teemed with treponemes for several weeks. Animals infected for eight or 10 weeks obtained quick resolution of their lesions by treatment with penicillin and were thereafter resistant to reinfection.

AB - The CB/Ss LAK strain of inbred hamster was used as a model for studies of infection with Treponema pertenue and of acquired resistance to it. When infected, this strain developed cutaneous lesions which lasted for six to seven months, even in the presence of peak titres of antitreponemal antibody. The rate of appearance and resolution of these lesions varied with the size of the inoculum. The infected hamsters' inguinal lymph nodes increased significantly in weight and teemed with treponemes for several weeks. Animals infected for eight or 10 weeks obtained quick resolution of their lesions by treatment with penicillin and were thereafter resistant to reinfection.

UR - http://www.scopus.com/inward/record.url?scp=0018610567&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0018610567&partnerID=8YFLogxK

M3 - Article

C2 - 509189

AN - SCOPUS:0018610567

VL - 55

SP - 316

EP - 319

JO - Sexually Transmitted Infections

JF - Sexually Transmitted Infections

SN - 1368-4973

IS - 5

ER -