Use of fibronectin and somatomedin-C as nutritional markers in the enteral nutrition support of traumatized patients

E. A. Buonpane, R. O. Brown, Bradley Boucher, T. C. Fabian, R. W. Luther

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Enteral nutrition support was provided to 12 critically ill, traumatized patients by continuous NG infusion with a nutritionally complete formula for at least 7 consecutive days. Serum for fibronectin (Fn) and somatomedin-C (Sm-C) was collected and nitrogen balance (NB) was measured on days 1, 4, 7, 14, 21, and 28 of the study period. Estimated energy and protein requirements were based, respectively, on the patient's calculated basal energy expenditure multiplied by a stress factor and urea nitrogen excretion (plus 4) during 24-h urine collections. Enteral feedings were started 5.3 ± 3.8 days after injury; patients received an average of 33.2 ± 3.9 kcal/kg · day and 1.5 ± 0.4 g protein/kg · day. Fn concentrations increased significantly (p < .05) from baseline on study days 7, 14, 21, and 28, whereas NB increased significantly (p < .05) on study days 4, 7, 14, 21, and 28. Significant correlations were found between Fn and NB (r = .52, p < .005), Fn and cumulative caloric intake (r = .54, p < .005), and Fn and cumulative nitrogen intake (r = .62, p < .005). There were no significant changes observed with Sm-C concentrations during the study period. Measurement of Fn concentrations appears to have potential as a nutrition support marker in traumatized patients, particularly in monitoring short courses of nutrition support. The role of Sm-C as a nutrition marker requires further investigation.

Original languageEnglish (US)
Pages (from-to)126-132
Number of pages7
JournalCritical Care Medicine
Volume17
Issue number2
DOIs
StatePublished - Jan 1 1989

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Enteral Nutrition
Insulin-Like Growth Factor I
Fibronectins
Nitrogen
Urine Specimen Collection
Energy Intake
Critical Illness
Energy Metabolism
Urea
Proteins
Wounds and Injuries
Serum

All Science Journal Classification (ASJC) codes

  • Critical Care and Intensive Care Medicine

Cite this

Use of fibronectin and somatomedin-C as nutritional markers in the enteral nutrition support of traumatized patients. / Buonpane, E. A.; Brown, R. O.; Boucher, Bradley; Fabian, T. C.; Luther, R. W.

In: Critical Care Medicine, Vol. 17, No. 2, 01.01.1989, p. 126-132.

Research output: Contribution to journalArticle

Buonpane, E. A. ; Brown, R. O. ; Boucher, Bradley ; Fabian, T. C. ; Luther, R. W. / Use of fibronectin and somatomedin-C as nutritional markers in the enteral nutrition support of traumatized patients. In: Critical Care Medicine. 1989 ; Vol. 17, No. 2. pp. 126-132.
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