Use of misoprostol on an outpatient basis for postdate pregnancy

J. H. Kipikasa, Charles Adair, J. Williamson, J. M. Breen, L. K. Medford, L. Sanchez-Ramos

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Objective: Within the obstetric community, several studies suggest that cervical ripening and labor induction after 40 weeks' gestation leads to improved maternal and neonatal outcomes. The most effective drug regimen to safely promote labor has not been determined. Method: Forty-nine subjects followed in an outpatient obstetrical clinic with pregnancies of at least 40 weeks' gestation, and an unfavorable Bishop score were assigned randomly to receive oral misoprostol 50 or 25 μg every 3 days for a maximum of three doses. Results: Twenty-three subjects received misoprostol 25 μg and 26 received 50 μg. The mean interval (±standard deviation) from start of cervical ripening to delivery was 2.4 days ±0.3 vs. 3.9 days ±0.7 for the 50 and 25 μg groups (P<0.05). No adverse events were noted. However, due to small sample size, less frequent adverse events may be missed. Type II errors cannot be excluded. Conclusion: In the prevention of postdate pregnancy, outpatients use of oral misoprostol 50 μg appears to result in earlier delivery, as compared to 25 μg.

Original languageEnglish (US)
Pages (from-to)108-111
Number of pages4
JournalInternational Journal of Gynecology and Obstetrics
Volume88
Issue number2
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

Fingerprint

Misoprostol
Outpatients
Cervical Ripening
Pregnancy
Induced Labor
Ambulatory Care Facilities
Sample Size
Obstetrics
Mothers
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Use of misoprostol on an outpatient basis for postdate pregnancy. / Kipikasa, J. H.; Adair, Charles; Williamson, J.; Breen, J. M.; Medford, L. K.; Sanchez-Ramos, L.

In: International Journal of Gynecology and Obstetrics, Vol. 88, No. 2, 01.01.2005, p. 108-111.

Research output: Contribution to journalArticle

Kipikasa, JH, Adair, C, Williamson, J, Breen, JM, Medford, LK & Sanchez-Ramos, L 2005, 'Use of misoprostol on an outpatient basis for postdate pregnancy', International Journal of Gynecology and Obstetrics, vol. 88, no. 2, pp. 108-111. https://doi.org/10.1016/j.ijgo.2004.10.006
Kipikasa, J. H. ; Adair, Charles ; Williamson, J. ; Breen, J. M. ; Medford, L. K. ; Sanchez-Ramos, L. / Use of misoprostol on an outpatient basis for postdate pregnancy. In: International Journal of Gynecology and Obstetrics. 2005 ; Vol. 88, No. 2. pp. 108-111.
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