Use of monoclonal antibody 17.13 in the diagnosis of human oral squamous cell carcinoma

Cesar A. Migliorati, Raymond Ranken, Michael Kaplan, Sol Silverman

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

We assessed the ability of monoclonal antibody (MAb) 17.13 to react with human oral squamous cell carcinoma (OSCC) and other oral tissues. MAb 17.13 was reacted with acetone‐fixed, serial frozen sections of 21 Oscc, 7 fibromas, 2 squamous papillomas, 1 melanosis and 3 normal oral mucosa, by means of an avidin‐biotin‐immunoperoxidase assay. Twenty‐one of 21 tumors (100% sensitivity) reacted strongly with MAb 17.13, with a homogenous staining pattern. Individual tumor cells could be clearly seen, improving the detection of microinvasion or borderline lesions. The epithelium of benign lesions and normal oral mucosa showed staining of the basal cells only. We conclude MAb 17.13 could be used as an accurate diagnostic tool for OSCC.

Original languageEnglish (US)
Pages (from-to)414-418
Number of pages5
JournalJournal of Oral Pathology & Medicine
Volume19
Issue number9
DOIs
StatePublished - Jan 1 1990

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Oral Diagnosis
Squamous Cell Carcinoma
Monoclonal Antibodies
Mouth Mucosa
Staining and Labeling
Melanosis
Fibroma
Papilloma
Frozen Sections
Neoplasms
Epithelium

All Science Journal Classification (ASJC) codes

  • Pathology and Forensic Medicine
  • Oral Surgery
  • Otorhinolaryngology
  • Cancer Research
  • Periodontics

Cite this

Use of monoclonal antibody 17.13 in the diagnosis of human oral squamous cell carcinoma. / Migliorati, Cesar A.; Ranken, Raymond; Kaplan, Michael; Silverman, Sol.

In: Journal of Oral Pathology & Medicine, Vol. 19, No. 9, 01.01.1990, p. 414-418.

Research output: Contribution to journalArticle

Migliorati, Cesar A. ; Ranken, Raymond ; Kaplan, Michael ; Silverman, Sol. / Use of monoclonal antibody 17.13 in the diagnosis of human oral squamous cell carcinoma. In: Journal of Oral Pathology & Medicine. 1990 ; Vol. 19, No. 9. pp. 414-418.
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