Use of presumptive antibiotics following tube thoracostomy for traumatic hemopneumothorax in the prevention of empyema and pneumonia - A multi-center trial

Robert Maxwell, Donald J. Campbell, Timothy C. Fabian, Martin Croce, Fred A. Luchette, Andrew J. Kerwin, Kimberly A. Davis, Kimberly Nagy, Samuel Tisherman, Michelle R. Holevar, Gregory A. Timberlake, Robert A. Maxwell

Research output: Contribution to journalArticle

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Abstract

Objective: To determine whether presumptive antibiotics reduce the risk of empyema or pneumonia following tube thoracostomy for traumatic hemopneumothorax. Methods: A prospective, randomized, double-blind trial was performed comparing the use of cefazolin for duration of tube thoracostomy placement (Group A) versus 24 hours (Group B) versus placebo (Group C). Results: A total of 224 patients received 229 tube thoracostomies. Logistic regression analysis revealed that duration of tube placement and thoracic acute injury score were predictive of empyema (p < 0.05). Empyema tended to occur more frequently in patients with penetrating injuries (p = 0.09). χ2 analysis showed pneumonia occurred significantly more frequently in blunt than penetrating injuries (p < 0.05). Presumptive antibiotic use did not significantly effect the incidence of empyema or pneumonia, although no empyemas occurred in Group A. Conclusions: The incidence of empyema was low and the use of presumptive antibiotics did not appear to reduce the risk of empyema or pneumonia.

Original languageEnglish (US)
Pages (from-to)742-749
Number of pages8
JournalJournal of Trauma - Injury, Infection and Critical Care
Volume57
Issue number4
DOIs
StatePublished - Oct 1 2004

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Hemopneumothorax
Thoracostomy
Empyema
Pneumonia
Anti-Bacterial Agents
Cefazolin
Thoracic Injuries
Nonpenetrating Wounds
Incidence
Logistic Models
Placebos
Regression Analysis
Wounds and Injuries

All Science Journal Classification (ASJC) codes

  • Surgery
  • Critical Care and Intensive Care Medicine

Cite this

Use of presumptive antibiotics following tube thoracostomy for traumatic hemopneumothorax in the prevention of empyema and pneumonia - A multi-center trial. / Maxwell, Robert; Campbell, Donald J.; Fabian, Timothy C.; Croce, Martin; Luchette, Fred A.; Kerwin, Andrew J.; Davis, Kimberly A.; Nagy, Kimberly; Tisherman, Samuel; Holevar, Michelle R.; Timberlake, Gregory A.; Maxwell, Robert A.

In: Journal of Trauma - Injury, Infection and Critical Care, Vol. 57, No. 4, 01.10.2004, p. 742-749.

Research output: Contribution to journalArticle

Maxwell, Robert ; Campbell, Donald J. ; Fabian, Timothy C. ; Croce, Martin ; Luchette, Fred A. ; Kerwin, Andrew J. ; Davis, Kimberly A. ; Nagy, Kimberly ; Tisherman, Samuel ; Holevar, Michelle R. ; Timberlake, Gregory A. ; Maxwell, Robert A. / Use of presumptive antibiotics following tube thoracostomy for traumatic hemopneumothorax in the prevention of empyema and pneumonia - A multi-center trial. In: Journal of Trauma - Injury, Infection and Critical Care. 2004 ; Vol. 57, No. 4. pp. 742-749.
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