Use of prothrombin complex concentrates in the treatment of a hemophilic patient with an inhibitor of factor VIII

T. Sonoda, Alan Solomon, S. Krauss, P. Cruz, F. S. Jones, J. Levin

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The course and treatment of a life threatening hemorrhagic episode in a patient with hemophilia A whose plasma contained a high concentration of an inhibitor of factor VIII activity is presented. The inhibitor of factor VIII was localized to the most anodal fractions of immunoglobulin G on electrophoresis, and was thus presumed to be an antibody directed against factor VIII. No therapeutic benefit occurred with infusions of massive amounts of fresh blood and factor VIII concentrates, or with a brief course of immunosuppressive therapy. Administration of standard and activated prothrombin complex concentrates resulted in reduction of the partial thromboplastin time to almost normal values and control of hemorrhagic episode occurred. Although a higher titer of inhibitor of factor VIII activity was still present in the patient's plasma, a beneficial therapeutic response was again achieved with standard prothrombin complex infusions.

Original languageEnglish (US)
Pages (from-to)983-989
Number of pages7
JournalBlood
Volume47
Issue number6
StatePublished - Dec 1 1976

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Factor VIII
Plasmas
Therapeutics
Partial Thromboplastin Time
Hemophilia A
Thromboplastin
Prothrombin
Immunosuppressive Agents
Electrophoresis
Reference Values
Blood
Immunoglobulin G
prothrombin complex concentrates
Antibodies

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Immunology
  • Hematology
  • Cell Biology

Cite this

Sonoda, T., Solomon, A., Krauss, S., Cruz, P., Jones, F. S., & Levin, J. (1976). Use of prothrombin complex concentrates in the treatment of a hemophilic patient with an inhibitor of factor VIII. Blood, 47(6), 983-989.

Use of prothrombin complex concentrates in the treatment of a hemophilic patient with an inhibitor of factor VIII. / Sonoda, T.; Solomon, Alan; Krauss, S.; Cruz, P.; Jones, F. S.; Levin, J.

In: Blood, Vol. 47, No. 6, 01.12.1976, p. 983-989.

Research output: Contribution to journalArticle

Sonoda, T, Solomon, A, Krauss, S, Cruz, P, Jones, FS & Levin, J 1976, 'Use of prothrombin complex concentrates in the treatment of a hemophilic patient with an inhibitor of factor VIII', Blood, vol. 47, no. 6, pp. 983-989.
Sonoda, T. ; Solomon, Alan ; Krauss, S. ; Cruz, P. ; Jones, F. S. ; Levin, J. / Use of prothrombin complex concentrates in the treatment of a hemophilic patient with an inhibitor of factor VIII. In: Blood. 1976 ; Vol. 47, No. 6. pp. 983-989.
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