Use of scaling theory to relate measurements of lung endothelial barrier permeability

T. R. Harris, Christopher Waters, F. R. Haselton

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

This work examined the relationships between lung microvascular permeability-surface area products (PS) for small solutes in animals of different size and for columns of endothelial-covered microcarrier beads. We assembled PS data (humans, sheep, lambs, and rabbits) for labeled sucrose, mannitol, urea, 1,2-propanediol, 1,3-propanediol, and 1,4-butanediol. In addition, PS for cell columns using sucrose, mannitol, and sodium fluorescein were evaluated. A new mathematical model for the analysis of cell columns that accounts for transit time variations was derived and compared with models neglecting this variation. Allometric relationships between PS and body weight or exchange surface (S) were examined. Permeability relative to diffusivity (P/D) correlated inversely with S for all animals. In addition, P/D for the cell columns fell near this regression line. The results suggest either that permeability for hydrophilic tracers is higher for smaller animals or that the indicator-dilution measurement is a fractal process dependent on scale. Furthermore, the P/D-S correlations may help relate cell column experiments to animal studies.

Original languageEnglish (US)
Pages (from-to)2496-2505
Number of pages10
JournalJournal of applied physiology
Volume77
Issue number5
DOIs
StatePublished - Jan 1 1994

Fingerprint

Permeability
Mannitol
Lung
Sucrose
Fractals
Propylene Glycol
Somatostatin-Secreting Cells
Capillary Permeability
Fluorescein
Urea
Sheep
Theoretical Models
Body Weight
Rabbits
1,3-butylene glycol
1,3-propanediol
1,4-butanediol

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Use of scaling theory to relate measurements of lung endothelial barrier permeability. / Harris, T. R.; Waters, Christopher; Haselton, F. R.

In: Journal of applied physiology, Vol. 77, No. 5, 01.01.1994, p. 2496-2505.

Research output: Contribution to journalArticle

Harris, T. R. ; Waters, Christopher ; Haselton, F. R. / Use of scaling theory to relate measurements of lung endothelial barrier permeability. In: Journal of applied physiology. 1994 ; Vol. 77, No. 5. pp. 2496-2505.
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