Use of thiopropyl sepharose for preparation of 2-nitro-5-thiobenzoic acid

Grace Han, Richard Blalock, Virgil Payne, Joan Han

Research output: Contribution to journalArticle

Abstract

A simple method is described for preparation of 2-nitro-5-thiobenzoic acid (NTB), a compound with versatile applications but is commercially unavailable. In this method, NTB is produced by the reduction of 5,5'-dithiobis(2-nitrobenzoic acid) (DTNB) with thiopropyl sepharose, which is then separated from NTB by filtration. Two molecules of NTB can be generated from each molecule of DTNB when a large excess of thiopropyl sepharose is used. Thiopropyl sepharose is commercially available and can be readily regenerated for repeated use in the preparation of NTB. This method is simple and more effective than any other reported methods of NTB preparation. (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)305-309
Number of pages5
JournalMicrochemical Journal
Volume65
Issue number3
DOIs
StatePublished - Nov 25 2000

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Dithionitrobenzoic Acid
Acids
Molecules
thiopropyl-sepharose
thionitrobenzoic acid

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Spectroscopy

Cite this

Use of thiopropyl sepharose for preparation of 2-nitro-5-thiobenzoic acid. / Han, Grace; Blalock, Richard; Payne, Virgil; Han, Joan.

In: Microchemical Journal, Vol. 65, No. 3, 25.11.2000, p. 305-309.

Research output: Contribution to journalArticle

Han, Grace ; Blalock, Richard ; Payne, Virgil ; Han, Joan. / Use of thiopropyl sepharose for preparation of 2-nitro-5-thiobenzoic acid. In: Microchemical Journal. 2000 ; Vol. 65, No. 3. pp. 305-309.
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