Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins

Lawrence Reiter, Ethan Bier

Research output: Contribution to journalReview article

29 Citations (Scopus)

Abstract

The fruit fly Drosophila melanogaster is a powerful genetic model organism, which has been instrumental in the determination of essential developmental and neurological pathways conserved from invertebrates to humans. With the completion of both the human and Drosophila genomes, the revelation that we are more similar to this simple organism than previously suspected was realised. 75% of human genetic disease genes have clear homologues in the fly. By utilising an array of genetic tools available to disrupt or misexpress these proteins, it is now feasible to perform large-scale genetic screens in Drosophila to identify other members of a particular human genetic pathway. This review outlines some of the reasons Drosophila is a useful tool for the discovery of therapeutic targets, covers some of the tools available to manipulate this organism and discusses specific examples of how to use Drosophila as a genetic test tube for revealing proteins which act in a common pathway.

Original languageEnglish (US)
Pages (from-to)387-399
Number of pages13
JournalExpert Opinion on Therapeutic Targets
Volume6
Issue number3
DOIs
StatePublished - Jul 2 2002
Externally publishedYes

Fingerprint

Drosophila melanogaster
Drosophila
Genes
Medical Genetics
Diptera
Pharmaceutical Preparations
Proteins
Fruits
Inborn Genetic Diseases
Genetic Models
Human Genome
Invertebrates
Fruit
Therapeutics

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Molecular Medicine

Cite this

Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins. / Reiter, Lawrence; Bier, Ethan.

In: Expert Opinion on Therapeutic Targets, Vol. 6, No. 3, 02.07.2002, p. 387-399.

Research output: Contribution to journalReview article

@article{55f707bff8354edcbd406e7737456bb8,
title = "Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins",
abstract = "The fruit fly Drosophila melanogaster is a powerful genetic model organism, which has been instrumental in the determination of essential developmental and neurological pathways conserved from invertebrates to humans. With the completion of both the human and Drosophila genomes, the revelation that we are more similar to this simple organism than previously suspected was realised. 75{\%} of human genetic disease genes have clear homologues in the fly. By utilising an array of genetic tools available to disrupt or misexpress these proteins, it is now feasible to perform large-scale genetic screens in Drosophila to identify other members of a particular human genetic pathway. This review outlines some of the reasons Drosophila is a useful tool for the discovery of therapeutic targets, covers some of the tools available to manipulate this organism and discusses specific examples of how to use Drosophila as a genetic test tube for revealing proteins which act in a common pathway.",
author = "Lawrence Reiter and Ethan Bier",
year = "2002",
month = "7",
day = "2",
doi = "10.1517/14728222.6.3.387",
language = "English (US)",
volume = "6",
pages = "387--399",
journal = "Expert Opinion on Therapeutic Targets",
issn = "1472-8222",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Using Drosophila melanogaster to uncover human disease gene function and potential drug target proteins

AU - Reiter, Lawrence

AU - Bier, Ethan

PY - 2002/7/2

Y1 - 2002/7/2

N2 - The fruit fly Drosophila melanogaster is a powerful genetic model organism, which has been instrumental in the determination of essential developmental and neurological pathways conserved from invertebrates to humans. With the completion of both the human and Drosophila genomes, the revelation that we are more similar to this simple organism than previously suspected was realised. 75% of human genetic disease genes have clear homologues in the fly. By utilising an array of genetic tools available to disrupt or misexpress these proteins, it is now feasible to perform large-scale genetic screens in Drosophila to identify other members of a particular human genetic pathway. This review outlines some of the reasons Drosophila is a useful tool for the discovery of therapeutic targets, covers some of the tools available to manipulate this organism and discusses specific examples of how to use Drosophila as a genetic test tube for revealing proteins which act in a common pathway.

AB - The fruit fly Drosophila melanogaster is a powerful genetic model organism, which has been instrumental in the determination of essential developmental and neurological pathways conserved from invertebrates to humans. With the completion of both the human and Drosophila genomes, the revelation that we are more similar to this simple organism than previously suspected was realised. 75% of human genetic disease genes have clear homologues in the fly. By utilising an array of genetic tools available to disrupt or misexpress these proteins, it is now feasible to perform large-scale genetic screens in Drosophila to identify other members of a particular human genetic pathway. This review outlines some of the reasons Drosophila is a useful tool for the discovery of therapeutic targets, covers some of the tools available to manipulate this organism and discusses specific examples of how to use Drosophila as a genetic test tube for revealing proteins which act in a common pathway.

UR - http://www.scopus.com/inward/record.url?scp=0036072565&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0036072565&partnerID=8YFLogxK

U2 - 10.1517/14728222.6.3.387

DO - 10.1517/14728222.6.3.387

M3 - Review article

VL - 6

SP - 387

EP - 399

JO - Expert Opinion on Therapeutic Targets

JF - Expert Opinion on Therapeutic Targets

SN - 1472-8222

IS - 3

ER -