Vacuolar trafficking and Candida albicans pathogenesis

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The vacuole is likely to play a variety of roles in supporting host coloni-zation and infection by pathogenic spe-cies of fungi. In the human pathogen Candida albicans, the vacuole undergoes dynamic morphological shifts during the production of the tissue invasive hyphal form, and this organelle is required for virulence. Recent efforts in my lab have focused on defining which vacuolar traf-ficking pathways are required for C. albi-cans hyphal growth and pathogenesis. Our results indicate that there are several distinct trafficking routes between the Golgi apparatus and vacuole. However, there is a large degree of functional over-lap between each with respect to their roles in hyphal growth and virulence. Herein we consider these results and pro-pose that during hyphal growth, specific trafficking routes maybe less important than the aggregate vacuolar trafficking capacity.

Original languageEnglish (US)
Pages (from-to)240-242
Number of pages3
JournalCommunicative and Integrative Biology
Volume4
Issue number2
DOIs
StatePublished - Mar 1 2011

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Vacuoles
Candida albicans
vacuoles
pathogenesis
Virulence
virulence
Growth
Golgi Apparatus
Golgi apparatus
cans
Organelles
organelles
Fungi
fungi
pathogens
Infection
infection

All Science Journal Classification (ASJC) codes

  • Agricultural and Biological Sciences(all)

Cite this

Vacuolar trafficking and Candida albicans pathogenesis. / Palmer, Glen.

In: Communicative and Integrative Biology, Vol. 4, No. 2, 01.03.2011, p. 240-242.

Research output: Contribution to journalArticle

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