Validating a nonhuman primate model of super-selective intraophthalmic artery chemotherapy

Comparing ophthalmic artery diameters

Lauren C. Ditta, Asim Choudhri, Brian C. Tse, Mark M. Landers, Barrett G. Haik, Jena J. Steinle, J. Scott Williams, Matthew Wilson

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

PURPOSE. Superselective intraophthalmic artery chemotherapy (SSIOAC) is being used for treatment of retinoblastoma; however, the hemodynamic consequences and toxicities are not fully known. We developed a nonhuman primate (NHP) model of SSIOAC and reported our clinical observations. For validation, we compared ophthalmic artery (OA) diameters between NHPs and children (<6 years). METHODS. Endovascular cannulation of the right OA was performed three times each in six adult male Rhesus macaques. Angiographic OA images were obtained and measured, and postmortem OAs were histologically sectioned and measured. Retrospectively, computed tomography (CT) and magnetic resonance (MR) angiography images of the head in children and adolescents (as an adult reference) were used to measure the OA luminal diameter at its origin. RESULTS. The median angiographic diameter of treated NHP OA origins (n=6) was 1.06 mm (range 0.94-1.56). Histologic measurements (8 of 12 NHP OAs) gave a median diameter of 1.09 mm (range 0.95-1.41). In 98 children (from 169 consecutive CT and MR angiography studies; median age 1.01 years, range 0.01-5.74), 186 OAs were measurable at the origin (median luminal diameter 1.28 mm, range 0.82-2.00; P = 0.16 for the angiographic NHP diameters versus pediatric cohort). Angiographic measurements of 34 OAs (of 20 consecutive studies of adolescents; median age 16.55 years, range 14.40-18.18) gave a median luminal diameter of 1.45 mm (origin, range 1.13-1.66; P < 0.0001, adolescent versus pediatric). CONCLUSIONS. Measurements of the OA luminal diameter at its origin were similar between our NHP and pediatric cohort, validating our NHP model for testing both the hemodynamic consequences and toxicities of SSIOAC.

Original languageEnglish (US)
Pages (from-to)7791-7794
Number of pages4
JournalInvestigative Ophthalmology and Visual Science
Volume53
Issue number12
DOIs
StatePublished - Nov 1 2012

Fingerprint

Ophthalmic Artery
Primates
Arteries
Drug Therapy
Magnetic Resonance Angiography
Pediatrics
Hemodynamics
Tomography
Retinoblastoma
Macaca mulatta
Catheterization
Head

All Science Journal Classification (ASJC) codes

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

Cite this

Validating a nonhuman primate model of super-selective intraophthalmic artery chemotherapy : Comparing ophthalmic artery diameters. / Ditta, Lauren C.; Choudhri, Asim; Tse, Brian C.; Landers, Mark M.; Haik, Barrett G.; Steinle, Jena J.; Williams, J. Scott; Wilson, Matthew.

In: Investigative Ophthalmology and Visual Science, Vol. 53, No. 12, 01.11.2012, p. 7791-7794.

Research output: Contribution to journalArticle

Ditta, Lauren C. ; Choudhri, Asim ; Tse, Brian C. ; Landers, Mark M. ; Haik, Barrett G. ; Steinle, Jena J. ; Williams, J. Scott ; Wilson, Matthew. / Validating a nonhuman primate model of super-selective intraophthalmic artery chemotherapy : Comparing ophthalmic artery diameters. In: Investigative Ophthalmology and Visual Science. 2012 ; Vol. 53, No. 12. pp. 7791-7794.
@article{bf7ff97cb4124637a20d8620f6798d70,
title = "Validating a nonhuman primate model of super-selective intraophthalmic artery chemotherapy: Comparing ophthalmic artery diameters",
abstract = "PURPOSE. Superselective intraophthalmic artery chemotherapy (SSIOAC) is being used for treatment of retinoblastoma; however, the hemodynamic consequences and toxicities are not fully known. We developed a nonhuman primate (NHP) model of SSIOAC and reported our clinical observations. For validation, we compared ophthalmic artery (OA) diameters between NHPs and children (<6 years). METHODS. Endovascular cannulation of the right OA was performed three times each in six adult male Rhesus macaques. Angiographic OA images were obtained and measured, and postmortem OAs were histologically sectioned and measured. Retrospectively, computed tomography (CT) and magnetic resonance (MR) angiography images of the head in children and adolescents (as an adult reference) were used to measure the OA luminal diameter at its origin. RESULTS. The median angiographic diameter of treated NHP OA origins (n=6) was 1.06 mm (range 0.94-1.56). Histologic measurements (8 of 12 NHP OAs) gave a median diameter of 1.09 mm (range 0.95-1.41). In 98 children (from 169 consecutive CT and MR angiography studies; median age 1.01 years, range 0.01-5.74), 186 OAs were measurable at the origin (median luminal diameter 1.28 mm, range 0.82-2.00; P = 0.16 for the angiographic NHP diameters versus pediatric cohort). Angiographic measurements of 34 OAs (of 20 consecutive studies of adolescents; median age 16.55 years, range 14.40-18.18) gave a median luminal diameter of 1.45 mm (origin, range 1.13-1.66; P < 0.0001, adolescent versus pediatric). CONCLUSIONS. Measurements of the OA luminal diameter at its origin were similar between our NHP and pediatric cohort, validating our NHP model for testing both the hemodynamic consequences and toxicities of SSIOAC.",
author = "Ditta, {Lauren C.} and Asim Choudhri and Tse, {Brian C.} and Landers, {Mark M.} and Haik, {Barrett G.} and Steinle, {Jena J.} and Williams, {J. Scott} and Matthew Wilson",
year = "2012",
month = "11",
day = "1",
doi = "10.1167/iovs.12-10605",
language = "English (US)",
volume = "53",
pages = "7791--7794",
journal = "Investigative Ophthalmology and Visual Science",
issn = "0146-0404",
publisher = "Association for Research in Vision and Ophthalmology Inc.",
number = "12",

}

TY - JOUR

T1 - Validating a nonhuman primate model of super-selective intraophthalmic artery chemotherapy

T2 - Comparing ophthalmic artery diameters

AU - Ditta, Lauren C.

AU - Choudhri, Asim

AU - Tse, Brian C.

AU - Landers, Mark M.

AU - Haik, Barrett G.

AU - Steinle, Jena J.

AU - Williams, J. Scott

AU - Wilson, Matthew

PY - 2012/11/1

Y1 - 2012/11/1

N2 - PURPOSE. Superselective intraophthalmic artery chemotherapy (SSIOAC) is being used for treatment of retinoblastoma; however, the hemodynamic consequences and toxicities are not fully known. We developed a nonhuman primate (NHP) model of SSIOAC and reported our clinical observations. For validation, we compared ophthalmic artery (OA) diameters between NHPs and children (<6 years). METHODS. Endovascular cannulation of the right OA was performed three times each in six adult male Rhesus macaques. Angiographic OA images were obtained and measured, and postmortem OAs were histologically sectioned and measured. Retrospectively, computed tomography (CT) and magnetic resonance (MR) angiography images of the head in children and adolescents (as an adult reference) were used to measure the OA luminal diameter at its origin. RESULTS. The median angiographic diameter of treated NHP OA origins (n=6) was 1.06 mm (range 0.94-1.56). Histologic measurements (8 of 12 NHP OAs) gave a median diameter of 1.09 mm (range 0.95-1.41). In 98 children (from 169 consecutive CT and MR angiography studies; median age 1.01 years, range 0.01-5.74), 186 OAs were measurable at the origin (median luminal diameter 1.28 mm, range 0.82-2.00; P = 0.16 for the angiographic NHP diameters versus pediatric cohort). Angiographic measurements of 34 OAs (of 20 consecutive studies of adolescents; median age 16.55 years, range 14.40-18.18) gave a median luminal diameter of 1.45 mm (origin, range 1.13-1.66; P < 0.0001, adolescent versus pediatric). CONCLUSIONS. Measurements of the OA luminal diameter at its origin were similar between our NHP and pediatric cohort, validating our NHP model for testing both the hemodynamic consequences and toxicities of SSIOAC.

AB - PURPOSE. Superselective intraophthalmic artery chemotherapy (SSIOAC) is being used for treatment of retinoblastoma; however, the hemodynamic consequences and toxicities are not fully known. We developed a nonhuman primate (NHP) model of SSIOAC and reported our clinical observations. For validation, we compared ophthalmic artery (OA) diameters between NHPs and children (<6 years). METHODS. Endovascular cannulation of the right OA was performed three times each in six adult male Rhesus macaques. Angiographic OA images were obtained and measured, and postmortem OAs were histologically sectioned and measured. Retrospectively, computed tomography (CT) and magnetic resonance (MR) angiography images of the head in children and adolescents (as an adult reference) were used to measure the OA luminal diameter at its origin. RESULTS. The median angiographic diameter of treated NHP OA origins (n=6) was 1.06 mm (range 0.94-1.56). Histologic measurements (8 of 12 NHP OAs) gave a median diameter of 1.09 mm (range 0.95-1.41). In 98 children (from 169 consecutive CT and MR angiography studies; median age 1.01 years, range 0.01-5.74), 186 OAs were measurable at the origin (median luminal diameter 1.28 mm, range 0.82-2.00; P = 0.16 for the angiographic NHP diameters versus pediatric cohort). Angiographic measurements of 34 OAs (of 20 consecutive studies of adolescents; median age 16.55 years, range 14.40-18.18) gave a median luminal diameter of 1.45 mm (origin, range 1.13-1.66; P < 0.0001, adolescent versus pediatric). CONCLUSIONS. Measurements of the OA luminal diameter at its origin were similar between our NHP and pediatric cohort, validating our NHP model for testing both the hemodynamic consequences and toxicities of SSIOAC.

UR - http://www.scopus.com/inward/record.url?scp=84872174301&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872174301&partnerID=8YFLogxK

U2 - 10.1167/iovs.12-10605

DO - 10.1167/iovs.12-10605

M3 - Article

VL - 53

SP - 7791

EP - 7794

JO - Investigative Ophthalmology and Visual Science

JF - Investigative Ophthalmology and Visual Science

SN - 0146-0404

IS - 12

ER -