Variable-region gene family usage for type II collagen autoantibodies in arthritis-susceptible DBA/1 mice

Xiu J. Ye, Tony Marion, Kuniaki Terato, Jacob A. Aelion, Michael A. Cremer, David M. Tillman, Marc S. Krug, Brian Jackson, Tai J. Yoo

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Collagen-induced arthritis is mediated by autoantibodies to type II collagen (CII). This experimental model has proven useful in determining the molecular and cellular mechanisms responsible for autoimmune arthritis. We have shown that polyarthritis can be transferred to normal mice by administrating combinations of three or four complement-fixing monoclonal antibodies (mAbs) which recognize cross-reactive epitopes on the α1(II)-CB11 region of chick and mouse CII. Currently, the light and heavy chain variable-region structures of a panel of α1(II)-CB11-specific mAbs that cross-react with chick and mouse CII, or react solely with chick CII, have been analyzed. The results indicate biased usage of V(K)19 and V(K)21 families of light-chain variable-region genes but random V(H) gene usage. Interestingly, two mAbs derived from different mice recognized identical epitopes on mouse CII and had nearly identical light- and heavy-chain variable region structure including junctionally derived sequence.

Original languageEnglish (US)
Pages (from-to)263-275
Number of pages13
JournalClinical Immunology and Immunopathology
Volume78
Issue number3
DOIs
StatePublished - Jan 1 1996

Fingerprint

Inbred DBA Mouse
Collagen Type II
Autoantibodies
Arthritis
Genes
Monoclonal Antibodies
Light
Epitopes
Experimental Arthritis
Theoretical Models

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Pathology and Forensic Medicine
  • Immunology

Cite this

Variable-region gene family usage for type II collagen autoantibodies in arthritis-susceptible DBA/1 mice. / Ye, Xiu J.; Marion, Tony; Terato, Kuniaki; Aelion, Jacob A.; Cremer, Michael A.; Tillman, David M.; Krug, Marc S.; Jackson, Brian; Yoo, Tai J.

In: Clinical Immunology and Immunopathology, Vol. 78, No. 3, 01.01.1996, p. 263-275.

Research output: Contribution to journalArticle

Ye, Xiu J. ; Marion, Tony ; Terato, Kuniaki ; Aelion, Jacob A. ; Cremer, Michael A. ; Tillman, David M. ; Krug, Marc S. ; Jackson, Brian ; Yoo, Tai J. / Variable-region gene family usage for type II collagen autoantibodies in arthritis-susceptible DBA/1 mice. In: Clinical Immunology and Immunopathology. 1996 ; Vol. 78, No. 3. pp. 263-275.
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