Vascular involvement in systemic sclerosis (scleroderma)

Research output: Contribution to journalReview article

55 Citations (Scopus)

Abstract

Systemic sclerosis (SSc) is an acquired multiorgan connective tissue disease with variable mortality and morbidity dictated by clinical subset type. The etiology of the basic disease and pathogenesis of the systemic autoimmunity, fibrosis, and fibroproliferative vasculopathy are unknown and debated. In this review, the spectrum of vascular abnormalities and the options currently available to treat the vascular manifestations of SSc are discussed. Also discussed is how the hallmark pathologies (ie, how autoimmunity, vasculopathy, and fibrosis of the disease) might be effected and interconnected with modulatory input from lysophospholipids, sphingosine 1-phosphate, and lysophosphatidic acid.

Original languageEnglish (US)
Pages (from-to)105-125
Number of pages21
JournalJournal of Inflammation Research
Volume4
Issue number1
StatePublished - Nov 7 2011

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Systemic Scleroderma
Autoimmunity
Blood Vessels
Fibrosis
Lysophospholipids
Connective Tissue Diseases
Pathology
Morbidity
Mortality
sphingosine 1-phosphate
lysophosphatidic acid

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

Vascular involvement in systemic sclerosis (scleroderma). / Pattanaik, Debendra; Brown, Monica; Postlethwaite, Arnold.

In: Journal of Inflammation Research, Vol. 4, No. 1, 07.11.2011, p. 105-125.

Research output: Contribution to journalReview article

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