Vasomotor symptoms and coronary artery calcium in postmenopausal women

Matthew A. Allison, Jo Ann E. Manson, Aaron Aragaki, Robert D. Langer, Jacques Rossouw, David Curb, Lisa W. Martin, Lawrence Phillips, Marcia L. Stefanick, Barbara B. Cochrane, Gloria Sarto, Janice Barnhart, Mary Jo O'Sullivan, Karen Johnson, Margery Gass, Maurizio Trevisan, Nancy F. Woods

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Objective: We assessed whether vasomotor symptoms (VMS) are associated with coronary artery calcium (CAC) and how hormone therapy (HT) may influence this association. Methods: Participants were a subset of women aged 50 to 59 years with a history of hysterectomy who were enrolled in the Women's Health Initiative (WHI) estrogen-alone clinical trial and underwent a CT scan of the chest at the end of the trial to determine CAC. Participants provided information about VMS (hot flashes and/or night sweats), as well as HT use, on self-administered questionnaires at trial baseline. Results: The sample consisted of 918 women with a mean (SD) age of 55.1 (2.8) years at WHI randomization and 64.8 (2.9) years at CAC ascertainment. The prevalence of a CAC score higher than 0 was 46%, whereas the prevalence of a CAC score of 10 or higher and higher than 100 was 39% and 19%, respectively. At randomization, 77% reported a history of any VMS at any time before or at enrollment in the WHI, whereas 20% reported any VMS present only at enrollment. Compared with those without a history of any VMS and after adjustment for potential confounders, a history of any VMS at any time up to and including WHI enrollment was associated with significantly reduced odds for CAC higher than 0 (odds ratio, 0.66; 95% CI, 0.45-0.98). Moreover, as duration of HT increased, the inverse association between any VMS and CAC moved toward the null. Conclusions: A history of any VMS was significantly associated with reduced odds for CAC independent of traditional cardiovascular disease risk factors and other relevant covariates. This association seems to be influenced by duration of HT.

Original languageEnglish (US)
Pages (from-to)1136-1145
Number of pages10
JournalMenopause
Volume17
Issue number6
DOIs
StatePublished - Nov 1 2010

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Coronary Vessels
Calcium
Women's Health
Hormones
Random Allocation
Hot Flashes
Sweat
Therapeutics
Hysterectomy
Estrogens
Cardiovascular Diseases
Thorax
Odds Ratio
Clinical Trials

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

Allison, M. A., Manson, J. A. E., Aragaki, A., Langer, R. D., Rossouw, J., Curb, D., ... Woods, N. F. (2010). Vasomotor symptoms and coronary artery calcium in postmenopausal women. Menopause, 17(6), 1136-1145. https://doi.org/10.1097/gme.0b013e3181e664dc

Vasomotor symptoms and coronary artery calcium in postmenopausal women. / Allison, Matthew A.; Manson, Jo Ann E.; Aragaki, Aaron; Langer, Robert D.; Rossouw, Jacques; Curb, David; Martin, Lisa W.; Phillips, Lawrence; Stefanick, Marcia L.; Cochrane, Barbara B.; Sarto, Gloria; Barnhart, Janice; O'Sullivan, Mary Jo; Johnson, Karen; Gass, Margery; Trevisan, Maurizio; Woods, Nancy F.

In: Menopause, Vol. 17, No. 6, 01.11.2010, p. 1136-1145.

Research output: Contribution to journalArticle

Allison, MA, Manson, JAE, Aragaki, A, Langer, RD, Rossouw, J, Curb, D, Martin, LW, Phillips, L, Stefanick, ML, Cochrane, BB, Sarto, G, Barnhart, J, O'Sullivan, MJ, Johnson, K, Gass, M, Trevisan, M & Woods, NF 2010, 'Vasomotor symptoms and coronary artery calcium in postmenopausal women', Menopause, vol. 17, no. 6, pp. 1136-1145. https://doi.org/10.1097/gme.0b013e3181e664dc
Allison MA, Manson JAE, Aragaki A, Langer RD, Rossouw J, Curb D et al. Vasomotor symptoms and coronary artery calcium in postmenopausal women. Menopause. 2010 Nov 1;17(6):1136-1145. https://doi.org/10.1097/gme.0b013e3181e664dc
Allison, Matthew A. ; Manson, Jo Ann E. ; Aragaki, Aaron ; Langer, Robert D. ; Rossouw, Jacques ; Curb, David ; Martin, Lisa W. ; Phillips, Lawrence ; Stefanick, Marcia L. ; Cochrane, Barbara B. ; Sarto, Gloria ; Barnhart, Janice ; O'Sullivan, Mary Jo ; Johnson, Karen ; Gass, Margery ; Trevisan, Maurizio ; Woods, Nancy F. / Vasomotor symptoms and coronary artery calcium in postmenopausal women. In: Menopause. 2010 ; Vol. 17, No. 6. pp. 1136-1145.
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T1 - Vasomotor symptoms and coronary artery calcium in postmenopausal women

AU - Allison, Matthew A.

AU - Manson, Jo Ann E.

AU - Aragaki, Aaron

AU - Langer, Robert D.

AU - Rossouw, Jacques

AU - Curb, David

AU - Martin, Lisa W.

AU - Phillips, Lawrence

AU - Stefanick, Marcia L.

AU - Cochrane, Barbara B.

AU - Sarto, Gloria

AU - Barnhart, Janice

AU - O'Sullivan, Mary Jo

AU - Johnson, Karen

AU - Gass, Margery

AU - Trevisan, Maurizio

AU - Woods, Nancy F.

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N2 - Objective: We assessed whether vasomotor symptoms (VMS) are associated with coronary artery calcium (CAC) and how hormone therapy (HT) may influence this association. Methods: Participants were a subset of women aged 50 to 59 years with a history of hysterectomy who were enrolled in the Women's Health Initiative (WHI) estrogen-alone clinical trial and underwent a CT scan of the chest at the end of the trial to determine CAC. Participants provided information about VMS (hot flashes and/or night sweats), as well as HT use, on self-administered questionnaires at trial baseline. Results: The sample consisted of 918 women with a mean (SD) age of 55.1 (2.8) years at WHI randomization and 64.8 (2.9) years at CAC ascertainment. The prevalence of a CAC score higher than 0 was 46%, whereas the prevalence of a CAC score of 10 or higher and higher than 100 was 39% and 19%, respectively. At randomization, 77% reported a history of any VMS at any time before or at enrollment in the WHI, whereas 20% reported any VMS present only at enrollment. Compared with those without a history of any VMS and after adjustment for potential confounders, a history of any VMS at any time up to and including WHI enrollment was associated with significantly reduced odds for CAC higher than 0 (odds ratio, 0.66; 95% CI, 0.45-0.98). Moreover, as duration of HT increased, the inverse association between any VMS and CAC moved toward the null. Conclusions: A history of any VMS was significantly associated with reduced odds for CAC independent of traditional cardiovascular disease risk factors and other relevant covariates. This association seems to be influenced by duration of HT.

AB - Objective: We assessed whether vasomotor symptoms (VMS) are associated with coronary artery calcium (CAC) and how hormone therapy (HT) may influence this association. Methods: Participants were a subset of women aged 50 to 59 years with a history of hysterectomy who were enrolled in the Women's Health Initiative (WHI) estrogen-alone clinical trial and underwent a CT scan of the chest at the end of the trial to determine CAC. Participants provided information about VMS (hot flashes and/or night sweats), as well as HT use, on self-administered questionnaires at trial baseline. Results: The sample consisted of 918 women with a mean (SD) age of 55.1 (2.8) years at WHI randomization and 64.8 (2.9) years at CAC ascertainment. The prevalence of a CAC score higher than 0 was 46%, whereas the prevalence of a CAC score of 10 or higher and higher than 100 was 39% and 19%, respectively. At randomization, 77% reported a history of any VMS at any time before or at enrollment in the WHI, whereas 20% reported any VMS present only at enrollment. Compared with those without a history of any VMS and after adjustment for potential confounders, a history of any VMS at any time up to and including WHI enrollment was associated with significantly reduced odds for CAC higher than 0 (odds ratio, 0.66; 95% CI, 0.45-0.98). Moreover, as duration of HT increased, the inverse association between any VMS and CAC moved toward the null. Conclusions: A history of any VMS was significantly associated with reduced odds for CAC independent of traditional cardiovascular disease risk factors and other relevant covariates. This association seems to be influenced by duration of HT.

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