Vasopressin responses to asphyxia and hemorrhage in newborn pigs

Charles Leffler, D. W. Busija, D. P. Brooks, J. T. Crofton, L. Share, D. G. Beasley, A. M. Fletcher

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Vasopressin may be important in maintenance of arterial pressure and redistribution of cardiac output in hypotensive and asphyxiated newborns. We used chronically instrumented, unanesthetized, 4-day-old pigs to investigate the effects of hypotensive hemorrhage and asphyxia on plasma vasopressin concentration and to determine the effects of cyclooxygenase inhibition on these responses. Asphyxia [arterial O2 partial pressure (Pa(O2)) = 40-50 Torr, arterial CO2 partial pressure (Pa(CO2)) = 60-80 Torr) increases plasma lysine vasopressin (LVP) from 2.2 ± 0.8 to 52.4 ± 15.0 μU/ml. Neither the baseline nor stimulated plasma LVP was affected by indomethacin (5 mg/kg) or meclofenamate (5 mg/kg). Hemorrhage (30 ml/kg) increased plasma LVP from 2.8 ± 0.8 to 163.4 ± 28.1 (20 min) and 135.1 ± 18.5 μU/ml (60 min). The effects of vehicle and indomethacin (5 mg/kg) 20 min after hemorrhage on plasma LVP 60 min after hemorrhage were not different. Changes in plasma vasopressin caused by asphyxia and hemorrhage in the unanesthetized newborn pig are similar to the responses observed in adults of other species. This study does not suggest that prostanoids are involved in these responses in newborn pigs.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Regulatory Integrative and Comparative Physiology
Volume252
Issue number1
StatePublished - Jun 19 1987

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Asphyxia
Vasopressins
Lypressin
Swine
Hemorrhage
Partial Pressure
Indomethacin
Meclofenamic Acid
Prostaglandin-Endoperoxide Synthases
Cardiac Output
Prostaglandins
Arterial Pressure
Maintenance

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Leffler, C., Busija, D. W., Brooks, D. P., Crofton, J. T., Share, L., Beasley, D. G., & Fletcher, A. M. (1987). Vasopressin responses to asphyxia and hemorrhage in newborn pigs. American Journal of Physiology - Regulatory Integrative and Comparative Physiology, 252(1).

Vasopressin responses to asphyxia and hemorrhage in newborn pigs. / Leffler, Charles; Busija, D. W.; Brooks, D. P.; Crofton, J. T.; Share, L.; Beasley, D. G.; Fletcher, A. M.

In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology, Vol. 252, No. 1, 19.06.1987.

Research output: Contribution to journalArticle

Leffler, C, Busija, DW, Brooks, DP, Crofton, JT, Share, L, Beasley, DG & Fletcher, AM 1987, 'Vasopressin responses to asphyxia and hemorrhage in newborn pigs', American Journal of Physiology - Regulatory Integrative and Comparative Physiology, vol. 252, no. 1.
Leffler, Charles ; Busija, D. W. ; Brooks, D. P. ; Crofton, J. T. ; Share, L. ; Beasley, D. G. ; Fletcher, A. M. / Vasopressin responses to asphyxia and hemorrhage in newborn pigs. In: American Journal of Physiology - Regulatory Integrative and Comparative Physiology. 1987 ; Vol. 252, No. 1.
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