Vasoreactivity in an adult rat model of marginal copper deficiency

Jeff C. Falcone, Jack T. Saari, Yujian Kang, Dale A. Schuschke

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Short-term severe copper deficiency has been shown to significantly reduce acetylcholine (Ach)-induced vascular smooth muscle relaxation. The current study was designed to examine the long-term relationship of marginal dietary Cu to vasoreactivity. Male adult rats were fed a purified diet with adequate (6.0 μg) or marginal (3.0 or 1.5 μg) Cu/g diet for 6 months. Luminal diameter changes were measured in isolated resistance arterioles. Liver and kidney Cu concentrations were used as indices of Cu status. The results showed a significant decrease in kidney Cu in the 1.5-μg group compared with the adequate controls but no effect on liver Cu. There was a significant correlation between dilation to 10-6 mol/L Ach and kidney Cu but no relationship between Cu status and 10-5 mol/L norepinephrine-induced constriction or flow-induced dilation. There was also no dietary effect on baseline vessel tone or dilator capacity. The data are the first to establish a linear relationship between Ach-induced vasodilation and systemic Cu status in a mature long-term model of marginal Cu deficiency.

Original languageEnglish (US)
Pages (from-to)177-186
Number of pages10
JournalNutrition Research
Volume25
Issue number2
DOIs
StatePublished - Jan 1 2005
Externally publishedYes

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Acetylcholine
Copper
Kidney
Dilatation
Diet
Muscle Relaxation
Liver
Arterioles
Vascular Smooth Muscle
Constriction
Vasodilation
Norepinephrine

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Nutrition and Dietetics

Cite this

Vasoreactivity in an adult rat model of marginal copper deficiency. / Falcone, Jeff C.; Saari, Jack T.; Kang, Yujian; Schuschke, Dale A.

In: Nutrition Research, Vol. 25, No. 2, 01.01.2005, p. 177-186.

Research output: Contribution to journalArticle

Falcone, Jeff C. ; Saari, Jack T. ; Kang, Yujian ; Schuschke, Dale A. / Vasoreactivity in an adult rat model of marginal copper deficiency. In: Nutrition Research. 2005 ; Vol. 25, No. 2. pp. 177-186.
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