Very long chain polyunsaturated fatty acids and rod cell structure and function

L. D. Marchette, D. M. Sherry, R. S. Brush, M. Chan, Y. Wen, J. Wang, John D. Ash, Robert E. Anderson, Nawajes Mandal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The gene encoding Elongation of Very Long Chain Fatty Acids-4 (ELOVL4) is mutated in patients with autosomal dominant Stargardt’s Macular Dystrophy Type 3 (STDG3). ELOVL4 catalyzes the initial condensation step in the elongation of polyunsaturated fatty acids (PUFA) containing more than 26 carbons (26C) to very long chain PUFA (VLC-PUFA; C28 and greater). To investigate the role of VLC-PUFA in rod photoreceptors, we generated mice with rod-specific deletion of Elovl4 (RcKO). The mosaic deletion of rod-expressed ELOVL4 protein resulted in a 36 % lower amount of VLC-PUFA in the retinal phosphatidylcholine (PC) fraction compared to retinas from wild-type mice. However, this reduction was not sufficient to cause rod dysfunction at 7 months or photoreceptor degeneration at 9 or 15 months.

Original languageEnglish (US)
Pages (from-to)637-645
Number of pages9
JournalAdvances in experimental medicine and biology
Volume801
DOIs
StatePublished - Jan 1 2014

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Unsaturated Fatty Acids
Elongation
Retinal Rod Photoreceptor Cells
Gene encoding
Macular Degeneration
Phosphatidylcholines
Retina
Condensation
Fatty Acids
Carbon
Genes
Proteins

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Very long chain polyunsaturated fatty acids and rod cell structure and function. / Marchette, L. D.; Sherry, D. M.; Brush, R. S.; Chan, M.; Wen, Y.; Wang, J.; Ash, John D.; Anderson, Robert E.; Mandal, Nawajes.

In: Advances in experimental medicine and biology, Vol. 801, 01.01.2014, p. 637-645.

Research output: Contribution to journalArticle

Marchette, LD, Sherry, DM, Brush, RS, Chan, M, Wen, Y, Wang, J, Ash, JD, Anderson, RE & Mandal, N 2014, 'Very long chain polyunsaturated fatty acids and rod cell structure and function', Advances in experimental medicine and biology, vol. 801, pp. 637-645. https://doi.org/10.1007/978-1-4614-3209-8_80
Marchette, L. D. ; Sherry, D. M. ; Brush, R. S. ; Chan, M. ; Wen, Y. ; Wang, J. ; Ash, John D. ; Anderson, Robert E. ; Mandal, Nawajes. / Very long chain polyunsaturated fatty acids and rod cell structure and function. In: Advances in experimental medicine and biology. 2014 ; Vol. 801. pp. 637-645.
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