Vesicular acetylcholine transport inhibitor suppresses REM sleep

M. Luisa Capece, S. Mbua Ngale Efange, Ralph Lydic

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

The vesamicol-like compound (±)-4-aminobenzovesamicol (ABV) non-competitively inhibits vesicular packaging of acetylcholine (ACh) in presynaptic terminals. This study tested the hypothesis that microinjection of ABV into the medial pontine reticular formation (mPRF) of intact, unanesthetized cats would inhibit rapid eye movement (REM) sleep. Microinjection of ABV alone or before administration of the acetylcholinesterase inhibitor neostigmine was used to evaluate the effects of ABV on natural REM sleep and on the neostigmine-induced REM sleep-like state. ABV decreased (24.8%) REM sleep and significantly reduced (33.6%) the neostigmine-induced REM sleep-like state. The results show for the first time that REM sleep generation can be disrupted by blocking a synaptic vesicle protein that modulates ACh transport in localized regions of the mPRF.

Original languageEnglish (US)
Pages (from-to)481-484
Number of pages4
JournalNeuroReport
Volume8
Issue number2
DOIs
StatePublished - Jan 1 1997
Externally publishedYes

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REM Sleep
Acetylcholine
Sleep
Neostigmine
Microinjections
Synaptic Vesicles
Cholinesterase Inhibitors
Presynaptic Terminals
Product Packaging
Cats
Proteins

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

Vesicular acetylcholine transport inhibitor suppresses REM sleep. / Capece, M. Luisa; Efange, S. Mbua Ngale; Lydic, Ralph.

In: NeuroReport, Vol. 8, No. 2, 01.01.1997, p. 481-484.

Research output: Contribution to journalArticle

Capece, M. Luisa ; Efange, S. Mbua Ngale ; Lydic, Ralph. / Vesicular acetylcholine transport inhibitor suppresses REM sleep. In: NeuroReport. 1997 ; Vol. 8, No. 2. pp. 481-484.
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