Visual-acuity development in healthy preterm infants

Effect of marine-oil supplementation

Susan E. Carlson, Susan H. Werkman, Philip G. Rhodes, Elizabeth Tolley

Research output: Contribution to journalArticle

398 Citations (Scopus)

Abstract

Docosahexaenoic acid (DHA; 22:6n - 3) is important for normal visual development. We hypothesized that preterm infants fed formulas with marine oil as a source of DHA would have better visual acuity than infants fed formulas without marine oil, as measured by the Teller Acuity Card procedure. Marine oil (P < 0.001) and age (P < 0.0001) influenced visual acuity, by repeated-measures analysis of variance (ANOVA) corrected for the effect of subject. Marine-oil-supplemented infants had better visual acuity than those fed standard formulas at 2 and 4 mo of age. by Fishers' least-squares difference (LSD). Acuity of both dietary groups improved through 6.5 mo of age. then plateaued. Through 4 mo of age. acuity was inversely related to oxygen supplementation (log10 h) and positively related to DHA status, by general-linear-models (GLM) analysis. After 4 mo of age. birth weight and gestational age were the only variables consistently related to visual acuity by GLM. We conclude that marine-oil-supplemented formula improved visual acuity of preterm infants through 4 mo of age by improving DHA status.

Original languageEnglish (US)
Pages (from-to)35-42
Number of pages8
JournalAmerican Journal of Clinical Nutrition
Volume58
Issue number1
DOIs
StatePublished - Jan 1 1993

Fingerprint

Premature Infants
Visual Acuity
Oils
Infant Formula
Linear Models
Docosahexaenoic Acids
Least-Squares Analysis
Birth Weight
Gestational Age
Analysis of Variance
Oxygen

All Science Journal Classification (ASJC) codes

  • Medicine (miscellaneous)
  • Nutrition and Dietetics

Cite this

Visual-acuity development in healthy preterm infants : Effect of marine-oil supplementation. / Carlson, Susan E.; Werkman, Susan H.; Rhodes, Philip G.; Tolley, Elizabeth.

In: American Journal of Clinical Nutrition, Vol. 58, No. 1, 01.01.1993, p. 35-42.

Research output: Contribution to journalArticle

Carlson, Susan E. ; Werkman, Susan H. ; Rhodes, Philip G. ; Tolley, Elizabeth. / Visual-acuity development in healthy preterm infants : Effect of marine-oil supplementation. In: American Journal of Clinical Nutrition. 1993 ; Vol. 58, No. 1. pp. 35-42.
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