Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons

Health ABC

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background. Although vitamin D has been mechanistically linked to insulin secretion and sensitivity, it remains unclear whether low 25-hydroxyvitamin D levels confer an increased risk of impaired glucose metabolism. We evaluated the relationship between vitamin D insufficiency (25-hydroxyvitamin D < 20ng/mL) and abnormal hemoglobin A1c (A1c) (≥6.5%) in community-dwelling older persons and examined whether this relationship differed according to race. Methods. Participants were 2,193 persons of age 70-79 years at Year 1 (52% women; 37% black) in the Health, Aging, and Body Composition study who had clinic visits at Years 2 and 4. Logistic regression analyses, adjusted for potential confounders, were used to evaluate the association between vitamin D insufficiency and abnormal A1c 2 years later. Interaction of race and vitamin D insufficiency was tested. Results. A total of 665 (30%) and 301 (14%) of the participants had vitamin D insufficiency at Year 2 and abnormal A1c at Year 4, respectively. After controlling for demographics, other potential confounders, and diabetes status at Year 4 (n = 477 diabetics), we found that vitamin D insufficiency was associated with an increased likelihood of having abnormal A1c (odds ratio = 1.56; 95% CI: 1.03-2.37). We also found that this relationship persisted among the 1,765 participants without diabetes in Year 2 (odds ratio = 2.33; 95% CI: 1.00-5.40). Findings did not differ by race. Conclusions. Vitamin D insufficiency was associated with abnormal A1c levels among black and white older persons independent of diabetes status. Future studies are needed to establish the temporal relationship between vitamin D and A1c in diverse samples of older persons.

Original languageEnglish (US)
Pages (from-to)525-531
Number of pages7
JournalJournals of Gerontology - Series A Biological Sciences and Medical Sciences
Volume70
Issue number4
DOIs
StatePublished - Apr 1 2015

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Abnormal Hemoglobins
Vitamin D
Odds Ratio
Independent Living
hydroquinone
Ambulatory Care
Body Composition
Insulin Resistance
Logistic Models
Regression Analysis
Demography
Glucose

All Science Journal Classification (ASJC) codes

  • Aging
  • Geriatrics and Gerontology

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Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons. / Health ABC.

In: Journals of Gerontology - Series A Biological Sciences and Medical Sciences, Vol. 70, No. 4, 01.04.2015, p. 525-531.

Research output: Contribution to journalArticle

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title = "Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons",
abstract = "Background. Although vitamin D has been mechanistically linked to insulin secretion and sensitivity, it remains unclear whether low 25-hydroxyvitamin D levels confer an increased risk of impaired glucose metabolism. We evaluated the relationship between vitamin D insufficiency (25-hydroxyvitamin D < 20ng/mL) and abnormal hemoglobin A1c (A1c) (≥6.5{\%}) in community-dwelling older persons and examined whether this relationship differed according to race. Methods. Participants were 2,193 persons of age 70-79 years at Year 1 (52{\%} women; 37{\%} black) in the Health, Aging, and Body Composition study who had clinic visits at Years 2 and 4. Logistic regression analyses, adjusted for potential confounders, were used to evaluate the association between vitamin D insufficiency and abnormal A1c 2 years later. Interaction of race and vitamin D insufficiency was tested. Results. A total of 665 (30{\%}) and 301 (14{\%}) of the participants had vitamin D insufficiency at Year 2 and abnormal A1c at Year 4, respectively. After controlling for demographics, other potential confounders, and diabetes status at Year 4 (n = 477 diabetics), we found that vitamin D insufficiency was associated with an increased likelihood of having abnormal A1c (odds ratio = 1.56; 95{\%} CI: 1.03-2.37). We also found that this relationship persisted among the 1,765 participants without diabetes in Year 2 (odds ratio = 2.33; 95{\%} CI: 1.00-5.40). Findings did not differ by race. Conclusions. Vitamin D insufficiency was associated with abnormal A1c levels among black and white older persons independent of diabetes status. Future studies are needed to establish the temporal relationship between vitamin D and A1c in diverse samples of older persons.",
author = "{Health ABC} and Jatupol Kositsawat and Kuchel, {George A.} and Tooze, {Janet A.} and Houston, {Denise K.} and Cauley, {Jane A.} and Kritchevsky, {Stephen B.} and Strotmeyer, {Elsa S.} and Kanaya, {Alka M.} and Harris, {Tamara B.} and Johnson, {Karen C.} and Karen Johnson",
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T1 - Vitamin D insufficiency and abnormal hemoglobin A1c in black and white older persons

AU - Health ABC

AU - Kositsawat, Jatupol

AU - Kuchel, George A.

AU - Tooze, Janet A.

AU - Houston, Denise K.

AU - Cauley, Jane A.

AU - Kritchevsky, Stephen B.

AU - Strotmeyer, Elsa S.

AU - Kanaya, Alka M.

AU - Harris, Tamara B.

AU - Johnson, Karen C.

AU - Johnson, Karen

PY - 2015/4/1

Y1 - 2015/4/1

N2 - Background. Although vitamin D has been mechanistically linked to insulin secretion and sensitivity, it remains unclear whether low 25-hydroxyvitamin D levels confer an increased risk of impaired glucose metabolism. We evaluated the relationship between vitamin D insufficiency (25-hydroxyvitamin D < 20ng/mL) and abnormal hemoglobin A1c (A1c) (≥6.5%) in community-dwelling older persons and examined whether this relationship differed according to race. Methods. Participants were 2,193 persons of age 70-79 years at Year 1 (52% women; 37% black) in the Health, Aging, and Body Composition study who had clinic visits at Years 2 and 4. Logistic regression analyses, adjusted for potential confounders, were used to evaluate the association between vitamin D insufficiency and abnormal A1c 2 years later. Interaction of race and vitamin D insufficiency was tested. Results. A total of 665 (30%) and 301 (14%) of the participants had vitamin D insufficiency at Year 2 and abnormal A1c at Year 4, respectively. After controlling for demographics, other potential confounders, and diabetes status at Year 4 (n = 477 diabetics), we found that vitamin D insufficiency was associated with an increased likelihood of having abnormal A1c (odds ratio = 1.56; 95% CI: 1.03-2.37). We also found that this relationship persisted among the 1,765 participants without diabetes in Year 2 (odds ratio = 2.33; 95% CI: 1.00-5.40). Findings did not differ by race. Conclusions. Vitamin D insufficiency was associated with abnormal A1c levels among black and white older persons independent of diabetes status. Future studies are needed to establish the temporal relationship between vitamin D and A1c in diverse samples of older persons.

AB - Background. Although vitamin D has been mechanistically linked to insulin secretion and sensitivity, it remains unclear whether low 25-hydroxyvitamin D levels confer an increased risk of impaired glucose metabolism. We evaluated the relationship between vitamin D insufficiency (25-hydroxyvitamin D < 20ng/mL) and abnormal hemoglobin A1c (A1c) (≥6.5%) in community-dwelling older persons and examined whether this relationship differed according to race. Methods. Participants were 2,193 persons of age 70-79 years at Year 1 (52% women; 37% black) in the Health, Aging, and Body Composition study who had clinic visits at Years 2 and 4. Logistic regression analyses, adjusted for potential confounders, were used to evaluate the association between vitamin D insufficiency and abnormal A1c 2 years later. Interaction of race and vitamin D insufficiency was tested. Results. A total of 665 (30%) and 301 (14%) of the participants had vitamin D insufficiency at Year 2 and abnormal A1c at Year 4, respectively. After controlling for demographics, other potential confounders, and diabetes status at Year 4 (n = 477 diabetics), we found that vitamin D insufficiency was associated with an increased likelihood of having abnormal A1c (odds ratio = 1.56; 95% CI: 1.03-2.37). We also found that this relationship persisted among the 1,765 participants without diabetes in Year 2 (odds ratio = 2.33; 95% CI: 1.00-5.40). Findings did not differ by race. Conclusions. Vitamin D insufficiency was associated with abnormal A1c levels among black and white older persons independent of diabetes status. Future studies are needed to establish the temporal relationship between vitamin D and A1c in diverse samples of older persons.

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DO - 10.1093/gerona/glu122

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