Vitamin D levels and menopause-related symptoms

Erin S. LeBlanc, Manisha Desai, Nancy Perrin, Jean Wactawski-Wende, Jo Ann E. Manson, Jane A. Cauley, Yvonne L. Michael, Jean Tang, Catherine Womack, Yiqing Song, Karen Johnson, Mary J. O'Sullivan, Nancy Woods, Marcia L. Stefanick

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Abstract

Objective: This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women.

Methods: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women's Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women's Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses.

Results: Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P's 9 0.10 for fully adjusted models).

Conclusions: There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.

Original languageEnglish (US)
Pages (from-to)1197-1203
Number of pages7
JournalMenopause
Volume21
Issue number11
DOIs
StatePublished - Nov 10 2014

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Menopause
Vitamin D
Women's Health
Fatigue
Sleep
Calcium
Serum

All Science Journal Classification (ASJC) codes

  • Obstetrics and Gynecology

Cite this

LeBlanc, E. S., Desai, M., Perrin, N., Wactawski-Wende, J., Manson, J. A. E., Cauley, J. A., ... Stefanick, M. L. (2014). Vitamin D levels and menopause-related symptoms. Menopause, 21(11), 1197-1203. https://doi.org/10.1097/gme.0000000000000238

Vitamin D levels and menopause-related symptoms. / LeBlanc, Erin S.; Desai, Manisha; Perrin, Nancy; Wactawski-Wende, Jean; Manson, Jo Ann E.; Cauley, Jane A.; Michael, Yvonne L.; Tang, Jean; Womack, Catherine; Song, Yiqing; Johnson, Karen; O'Sullivan, Mary J.; Woods, Nancy; Stefanick, Marcia L.

In: Menopause, Vol. 21, No. 11, 10.11.2014, p. 1197-1203.

Research output: Contribution to journalArticle

LeBlanc, ES, Desai, M, Perrin, N, Wactawski-Wende, J, Manson, JAE, Cauley, JA, Michael, YL, Tang, J, Womack, C, Song, Y, Johnson, K, O'Sullivan, MJ, Woods, N & Stefanick, ML 2014, 'Vitamin D levels and menopause-related symptoms', Menopause, vol. 21, no. 11, pp. 1197-1203. https://doi.org/10.1097/gme.0000000000000238
LeBlanc ES, Desai M, Perrin N, Wactawski-Wende J, Manson JAE, Cauley JA et al. Vitamin D levels and menopause-related symptoms. Menopause. 2014 Nov 10;21(11):1197-1203. https://doi.org/10.1097/gme.0000000000000238
LeBlanc, Erin S. ; Desai, Manisha ; Perrin, Nancy ; Wactawski-Wende, Jean ; Manson, Jo Ann E. ; Cauley, Jane A. ; Michael, Yvonne L. ; Tang, Jean ; Womack, Catherine ; Song, Yiqing ; Johnson, Karen ; O'Sullivan, Mary J. ; Woods, Nancy ; Stefanick, Marcia L. / Vitamin D levels and menopause-related symptoms. In: Menopause. 2014 ; Vol. 21, No. 11. pp. 1197-1203.
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abstract = "Objective: This study aims to determine whether vitamin D levels are associated with menopause-related symptoms in older women.Methods: A randomly selected subset of 1,407 women, among 26,104 potentially eligible participants of the Women's Health Initiative Calcium and Vitamin D trial of postmenopausal women aged 51 to 80 years, had 25-hydroxyvitamin D [25(OH)D] levels measured at the Women's Health Initiative Calcium and Vitamin D trial baseline visit. Information about menopause-related symptoms at baseline was obtained by questionnaire and included overall number of symptoms and composite measures of sleep disturbance, emotional well-being, and energy/fatigue, as well as individual symptoms. After exclusions for missing data, 530 women (mean [SD] age, 66.2 [6.8] y) were included in these analyses.Results: Borderline significant associations between 25(OH)D levels and total number of menopausal symptoms were observed (with P values ranging from 0.05 to 0.06 for fully adjusted models); however, the effect was clinically insignificant and disappeared with correction for multiple testing. No associations between 25(OH)D levels and composite measures of sleep disturbance, emotional well-being, or energy/fatigue were observed (P's 9 0.10 for fully adjusted models).Conclusions: There is no evidence for a clinically important association between serum 25(OH)D levels and menopause-related symptoms in postmenopausal women.",
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