Vitamin d metabolism in familial benign hypercalcemia (hypocalciuric hypercalcemia) differs from that in primary hyperparathyroidism

William Law, Susan Bollman, Rajiv Kumar, Hunter Heath

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

We compared serum concentrations of immunoreactive PTH and plasma levels of vitamin Dmetabolites in 11 patients with adenomatous primary hyperparathyroidism and 32 individuals with the syndrome of familial benign hypercalcemia or familial hypocalciuric hypercalcemia (FHH). Serum immunoreactive PTH was elevated in the hyperparathyroid group but indistinguishable from control inFHH, despite comparable degrees of hypercalcemia. Plasma 25-hydroxyvitamin D concentrations were normal in both groups, but plasma 1,25-dihydroxyvitamin D levels in FHH were significantly lower than control (P < 0.0025) or hyperparathyroid (P < 0.01)values. FHH is pathogenetically distinct from primary hyperparathyroidism and should not be thought of simply as a variant of that condition.

Original languageEnglish (US)
Pages (from-to)744-747
Number of pages4
JournalJournal of Clinical Endocrinology and Metabolism
Volume58
Issue number4
DOIs
StatePublished - Jan 1 1984
Externally publishedYes

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Primary Hyperparathyroidism
Hypercalcemia
Metabolism
Vitamins
Plasmas
Serum
Control Groups
Hypocalciuric hypercalcemia, familial, type 1

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Biochemistry
  • Endocrinology
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Vitamin d metabolism in familial benign hypercalcemia (hypocalciuric hypercalcemia) differs from that in primary hyperparathyroidism. / Law, William; Bollman, Susan; Kumar, Rajiv; Heath, Hunter.

In: Journal of Clinical Endocrinology and Metabolism, Vol. 58, No. 4, 01.01.1984, p. 744-747.

Research output: Contribution to journalArticle

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