Vitamin D receptor Bsm1 polymorphism, calcium metabolism and bone mineral density in patients with multiple sclerosis

A pilot study

Irene Lambrinoudaki, Elias Patikas, George Kaparos, Eleni Armeni, Demetrios Rizos, Pinelopi Thoda, Andreas Alexandrou, Aristidis Antoniou, Georgios Tsivgoulis, Stergios Gatzonis, Constantinos Panoulis, Nikolaos Triantafyllou

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Vitamin D receptor's (VDR) genotypes have been associated both with the development of bone disease and the pathogenesis of multiple sclerosis (MS). We aimed to evaluate the association between the presence of Bsm1 restriction fragment length polymorphism of VDR and bone loss in ambulatory patients with MS. This cross-sectional study included 82 adult patients with relapsing-remitting MS. Fasting blood samples were obtained for biochemical-hormonal assessment and genotyping. Bone mineral density (BMD) was assessed at the lumbar spine (LS) and the femoral neck (FN), using dual energy X-ray absorptiometry. Possible associations between VDR's genotypes and BMD levels as well as biochemical and hormonal indices were evaluated. Among premenopausal women and men, carriers of the B allele exhibited higher BMD and Z score at the FN and a trend toward higher BMD at the LS, compared to patients with the bb genotype, after adjusting for age, BMI, sex, EDSS scoring, interferon administration, duration of MS and total steroids intake. Among postmenopausal women, the presence of the B allele was not associated with BMD or T score at any site, whereas carriers of the B allele exhibited higher levels of calcium (p value 0.008, univariate). No other significant differences were exhibited between levels of electrolytes, parathormone, 25-hydroxyvitamin D 3 and the genotype of VDR, in any of the groups. VDR's Bsm1 polymorphism is associated with a mild effect on BMD in younger patients with MS. Larger studies are necessary to corroborate these findings.

Original languageEnglish (US)
Pages (from-to)1433-1439
Number of pages7
JournalNeurological Sciences
Volume34
Issue number8
DOIs
StatePublished - Aug 1 2013
Externally publishedYes

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Calcitriol Receptors
Bone Density
Multiple Sclerosis
Calcium
Genotype
Alleles
Femur Neck
Spine
Calcifediol
Relapsing-Remitting Multiple Sclerosis
Bone Diseases
Photon Absorptiometry
Parathyroid Hormone
Restriction Fragment Length Polymorphisms
Interferons
Electrolytes
Fasting
Cross-Sectional Studies
Steroids
Bone and Bones

All Science Journal Classification (ASJC) codes

  • Dermatology
  • Clinical Neurology
  • Psychiatry and Mental health

Cite this

Lambrinoudaki, I., Patikas, E., Kaparos, G., Armeni, E., Rizos, D., Thoda, P., ... Triantafyllou, N. (2013). Vitamin D receptor Bsm1 polymorphism, calcium metabolism and bone mineral density in patients with multiple sclerosis: A pilot study. Neurological Sciences, 34(8), 1433-1439. https://doi.org/10.1007/s10072-012-1259-7

Vitamin D receptor Bsm1 polymorphism, calcium metabolism and bone mineral density in patients with multiple sclerosis : A pilot study. / Lambrinoudaki, Irene; Patikas, Elias; Kaparos, George; Armeni, Eleni; Rizos, Demetrios; Thoda, Pinelopi; Alexandrou, Andreas; Antoniou, Aristidis; Tsivgoulis, Georgios; Gatzonis, Stergios; Panoulis, Constantinos; Triantafyllou, Nikolaos.

In: Neurological Sciences, Vol. 34, No. 8, 01.08.2013, p. 1433-1439.

Research output: Contribution to journalArticle

Lambrinoudaki, I, Patikas, E, Kaparos, G, Armeni, E, Rizos, D, Thoda, P, Alexandrou, A, Antoniou, A, Tsivgoulis, G, Gatzonis, S, Panoulis, C & Triantafyllou, N 2013, 'Vitamin D receptor Bsm1 polymorphism, calcium metabolism and bone mineral density in patients with multiple sclerosis: A pilot study', Neurological Sciences, vol. 34, no. 8, pp. 1433-1439. https://doi.org/10.1007/s10072-012-1259-7
Lambrinoudaki, Irene ; Patikas, Elias ; Kaparos, George ; Armeni, Eleni ; Rizos, Demetrios ; Thoda, Pinelopi ; Alexandrou, Andreas ; Antoniou, Aristidis ; Tsivgoulis, Georgios ; Gatzonis, Stergios ; Panoulis, Constantinos ; Triantafyllou, Nikolaos. / Vitamin D receptor Bsm1 polymorphism, calcium metabolism and bone mineral density in patients with multiple sclerosis : A pilot study. In: Neurological Sciences. 2013 ; Vol. 34, No. 8. pp. 1433-1439.
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