Vitamin K Dependent Proteins of Bone and Cartilage

Caren M. Gundberg, Satoru Nishimoto

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Citations (Scopus)

Abstract

The importance of vitamin K for the normal functioning of blood coagulation factors is well known. However, this vitamin is also involved in the physiological activation of various proteins that are not involved in hemostasis. This chapter focuses on the biochemistry and physiology of ostocalcin and Matrix Gla Protein (MGP), which are abundant in bone and cartilage, respectively. While ostocalcin biosynthesis is restricted to bone and dentin, MGP is synthesized in a variety of tissues and cell types. Two other vitamin K-dependent proteins, Gas6, which is involved in the regulation of cell proliferation and Protein S, an inhibitor of coagulation, have been shown to have a potential role in bone metabolism.

Original languageEnglish (US)
Title of host publicationDynamics of Bone and Cartilage Metabolism
PublisherElsevier Inc.
Pages55-70
Number of pages16
ISBN (Print)9780120885626
DOIs
StatePublished - Dec 1 2006

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Vitamin K
Osteocalcin
Cartilage
Bone and Bones
Bone Matrix
Blood Coagulation Factors
Protein S
Dentin
Hemostasis
Vitamins
Biochemistry
Proteins
Cell Proliferation
matrix Gla protein

All Science Journal Classification (ASJC) codes

  • Dentistry(all)
  • Medicine(all)

Cite this

Gundberg, C. M., & Nishimoto, S. (2006). Vitamin K Dependent Proteins of Bone and Cartilage. In Dynamics of Bone and Cartilage Metabolism (pp. 55-70). Elsevier Inc.. https://doi.org/10.1016/B978-012088562-6/50004-2

Vitamin K Dependent Proteins of Bone and Cartilage. / Gundberg, Caren M.; Nishimoto, Satoru.

Dynamics of Bone and Cartilage Metabolism. Elsevier Inc., 2006. p. 55-70.

Research output: Chapter in Book/Report/Conference proceedingChapter

Gundberg, CM & Nishimoto, S 2006, Vitamin K Dependent Proteins of Bone and Cartilage. in Dynamics of Bone and Cartilage Metabolism. Elsevier Inc., pp. 55-70. https://doi.org/10.1016/B978-012088562-6/50004-2
Gundberg CM, Nishimoto S. Vitamin K Dependent Proteins of Bone and Cartilage. In Dynamics of Bone and Cartilage Metabolism. Elsevier Inc. 2006. p. 55-70 https://doi.org/10.1016/B978-012088562-6/50004-2
Gundberg, Caren M. ; Nishimoto, Satoru. / Vitamin K Dependent Proteins of Bone and Cartilage. Dynamics of Bone and Cartilage Metabolism. Elsevier Inc., 2006. pp. 55-70
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