Vitamin K2 in electron transport system

Are enzymes involved in vitamin K2 biosynthesis promising drug targets?

Michio Kurosu, Eeshwaraiah Begari

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Aerobic and anaerobic respiratory systems allow cells to transport the electrons to terminal electron acceptors. The quinone (ubiquinone or menaquinone) pool is central to the electron transport chain. In the majority of Gram-positive bacteria, vitamin K2 (menaquinone) is the sole quinone in the electron transport chain, and thus, the bacterial enzymes catalyzing the synthesis of menaquinone are potential targets for the development of novel antibacterial drugs. This manuscript reviews the role of vitamin K in bacteria and humans, and especially emphasizes on recent aspects of menaquinones in bacterial electron transport chain and on discoveries of inhibitor molecules targeting bacterial electron transport systems for new antibacterial agents.

Original languageEnglish (US)
Pages (from-to)1531-1553
Number of pages23
JournalMolecules
Volume15
Issue number3
DOIs
StatePublished - Mar 1 2010

Fingerprint

Vitamin K 2
vitamins
biosynthesis
Biosynthesis
Electron Transport
enzymes
drugs
Enzymes
Pharmaceutical Preparations
electrons
quinones
Bacteria
bacteria
Respiratory system
phylloquinone
respiratory system
Ubiquinone
Vitamin K
Electrons
Gram-Positive Bacteria

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Vitamin K2 in electron transport system : Are enzymes involved in vitamin K2 biosynthesis promising drug targets? / Kurosu, Michio; Begari, Eeshwaraiah.

In: Molecules, Vol. 15, No. 3, 01.03.2010, p. 1531-1553.

Research output: Contribution to journalReview article

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