Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women

The health, aging, and body composition study

G. N. Farhat, E. S. Strotmeyer, A. B. Newman, K. Sutton-Tyrrell, D. C. Bauer, T. Harris, Karen Johnson, D. R. Taaffe, J. A. Cauley

Research output: Contribution to journalArticle

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Abstract

The associations of volumetric (vBMD) and areal (aBMD) bone mineral density measures with prevalent cardiovascular disease (CVD) and subclinical peripheral arterial disease (PAD) were investigated in a cohort of older men and women enrolled in the Health, Aging, and Body Composition Study. Participants were 3,075 well-functioning white and black men and women (42% black, 51% women), aged 68-80 years. Total hip, femoral neck, and trochanter aBMD were measured using dual-energy X-ray absorptiometry. Quantitative computed tomography was used to evaluate spine trabecular, integral, and cortical vBMD measures in a subgroup (n = 1,489). Logistic regression was performed to examine associations of BMD measures with CVD and PAD. The prevalence of CVD (defined by coronary heart disease, PAD, cerebrovascular disease, or congestive heart failure) was 29.8%. Among participants without CVD, 10% had subclinical PAD (defined as ankle-arm index <0.9). Spine vBMD measures were inversely associated with CVD in men (odds ratio of integral [ORintegral] = 1.34, 95% confidence interval [CI] 1.10-1.63; ORtrabecular = 1.25, 95% CI 1.02-1.53; ORcortical = 1.36, 95% CI 1.11-1.65). In women, for each standard deviation decrease in integral vBMD, cortical vBMD, or trochanter aBMD, the odds of CVD were significantly increased by 28%, 27%, and 22%, respectively. Total hip aBMD was associated with subclinical PAD in men (OR = 1.39, 95% CI 1.03-1.84) but not in women. All associations were independent of age and shared risk factors between BMD and CVD and were not influenced by inflammatory cytokines (interleukin-6 and tumor necrosis factors-α). In conclusion, our results provide further evidence for an inverse association between BMD and CVD in men and women. Future research should investigate common pathophysiological links for osteoporosis and CVD.

Original languageEnglish (US)
Pages (from-to)102-111
Number of pages10
JournalCalcified Tissue International
Volume79
Issue number2
DOIs
StatePublished - Aug 1 2006

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Women's Health
Body Composition
Bone Density
Cardiovascular Diseases
Peripheral Arterial Disease
Confidence Intervals
Femur
Hip
Spine
Tumor Necrosis Factors
Cerebrovascular Disorders
Femur Neck
Photon Absorptiometry
Ankle
Osteoporosis
Coronary Disease
Interleukin-6
Arm
Heart Failure
Logistic Models

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Orthopedics and Sports Medicine
  • Endocrinology

Cite this

Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women : The health, aging, and body composition study. / Farhat, G. N.; Strotmeyer, E. S.; Newman, A. B.; Sutton-Tyrrell, K.; Bauer, D. C.; Harris, T.; Johnson, Karen; Taaffe, D. R.; Cauley, J. A.

In: Calcified Tissue International, Vol. 79, No. 2, 01.08.2006, p. 102-111.

Research output: Contribution to journalArticle

Farhat, G. N. ; Strotmeyer, E. S. ; Newman, A. B. ; Sutton-Tyrrell, K. ; Bauer, D. C. ; Harris, T. ; Johnson, Karen ; Taaffe, D. R. ; Cauley, J. A. / Volumetric and areal bone mineral density measures are associated with cardiovascular disease in older men and women : The health, aging, and body composition study. In: Calcified Tissue International. 2006 ; Vol. 79, No. 2. pp. 102-111.
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abstract = "The associations of volumetric (vBMD) and areal (aBMD) bone mineral density measures with prevalent cardiovascular disease (CVD) and subclinical peripheral arterial disease (PAD) were investigated in a cohort of older men and women enrolled in the Health, Aging, and Body Composition Study. Participants were 3,075 well-functioning white and black men and women (42{\%} black, 51{\%} women), aged 68-80 years. Total hip, femoral neck, and trochanter aBMD were measured using dual-energy X-ray absorptiometry. Quantitative computed tomography was used to evaluate spine trabecular, integral, and cortical vBMD measures in a subgroup (n = 1,489). Logistic regression was performed to examine associations of BMD measures with CVD and PAD. The prevalence of CVD (defined by coronary heart disease, PAD, cerebrovascular disease, or congestive heart failure) was 29.8{\%}. Among participants without CVD, 10{\%} had subclinical PAD (defined as ankle-arm index <0.9). Spine vBMD measures were inversely associated with CVD in men (odds ratio of integral [ORintegral] = 1.34, 95{\%} confidence interval [CI] 1.10-1.63; ORtrabecular = 1.25, 95{\%} CI 1.02-1.53; ORcortical = 1.36, 95{\%} CI 1.11-1.65). In women, for each standard deviation decrease in integral vBMD, cortical vBMD, or trochanter aBMD, the odds of CVD were significantly increased by 28{\%}, 27{\%}, and 22{\%}, respectively. Total hip aBMD was associated with subclinical PAD in men (OR = 1.39, 95{\%} CI 1.03-1.84) but not in women. All associations were independent of age and shared risk factors between BMD and CVD and were not influenced by inflammatory cytokines (interleukin-6 and tumor necrosis factors-α). In conclusion, our results provide further evidence for an inverse association between BMD and CVD in men and women. Future research should investigate common pathophysiological links for osteoporosis and CVD.",
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