Wedge resection for non-small cell lung cancer in patients with pulmonary insufficiency: Prospective ten-year survival

John P. Griffin, Charles E. Eastridge, Elizabeth Tolley, James W. Pate

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

BACKGROUND: Possibility of curative resection by lobectomy for non-small cell lung cancer is often denied patients with compromised pulmonary reserve. Analysis of survival of such patients treated by wedge resection was compared with that of patients treated by standard resection, with both groups followed for 10 years. DESIGN: A prospective 5-year cohort study. METHODS: From 1988 to 1992, an observational cohort of 127 consecutive resected patients at Memphis VA Medical Center was divided into those receiving lobectomy in 81 cases and pneumonectomy in 15 cases (group I) versus 31 patients with compromised pulmonary reserve (group II), who had complete tumor excision by wedge resection. Preoperative clinical staging was corrected to surgical-pathological staging after demonstration of its superiority. Survival estimates were obtained by Kaplan-Meier method with curves compared by log rank tests, with all-cause mortality calculated from date of surgery. RESULTS: Extent of disease in group I was 58% stage I, 19% stage II, and 23% stage III. In group II, extent of disease was 84% stage I, 3% stage II, and 14% stage III. Group I median survival was 26 months with 30% 5-year survival; for group II, median survival was 30 months and 32%. Kaplan-Meier survival plots showed similar curves in groups I and II. Realizing less extent of disease in group II, another Kaplan-Meier plot restricted to stage I and II patients showed overlapping survival curves for groups I and II. CONCLUSION: Survival during 10-year observation was similar for patients with pulmonary insufficiency treated by wedge resection to that of patients receiving standard resection in this single-institution consecutive cohort.

Original languageEnglish (US)
Pages (from-to)960-964
Number of pages5
JournalJournal of Thoracic Oncology
Volume1
Issue number9
DOIs
StatePublished - Nov 1 2006

Fingerprint

Non-Small Cell Lung Carcinoma
Lung
Survival
Pneumonectomy
Survival Analysis
Cohort Studies
Observation
Mortality
Neoplasms

All Science Journal Classification (ASJC) codes

  • Oncology
  • Pulmonary and Respiratory Medicine

Cite this

Wedge resection for non-small cell lung cancer in patients with pulmonary insufficiency : Prospective ten-year survival. / Griffin, John P.; Eastridge, Charles E.; Tolley, Elizabeth; Pate, James W.

In: Journal of Thoracic Oncology, Vol. 1, No. 9, 01.11.2006, p. 960-964.

Research output: Contribution to journalArticle

@article{0ab98ac7fc8748fe9e7dc4c46b35d4ca,
title = "Wedge resection for non-small cell lung cancer in patients with pulmonary insufficiency: Prospective ten-year survival",
abstract = "BACKGROUND: Possibility of curative resection by lobectomy for non-small cell lung cancer is often denied patients with compromised pulmonary reserve. Analysis of survival of such patients treated by wedge resection was compared with that of patients treated by standard resection, with both groups followed for 10 years. DESIGN: A prospective 5-year cohort study. METHODS: From 1988 to 1992, an observational cohort of 127 consecutive resected patients at Memphis VA Medical Center was divided into those receiving lobectomy in 81 cases and pneumonectomy in 15 cases (group I) versus 31 patients with compromised pulmonary reserve (group II), who had complete tumor excision by wedge resection. Preoperative clinical staging was corrected to surgical-pathological staging after demonstration of its superiority. Survival estimates were obtained by Kaplan-Meier method with curves compared by log rank tests, with all-cause mortality calculated from date of surgery. RESULTS: Extent of disease in group I was 58{\%} stage I, 19{\%} stage II, and 23{\%} stage III. In group II, extent of disease was 84{\%} stage I, 3{\%} stage II, and 14{\%} stage III. Group I median survival was 26 months with 30{\%} 5-year survival; for group II, median survival was 30 months and 32{\%}. Kaplan-Meier survival plots showed similar curves in groups I and II. Realizing less extent of disease in group II, another Kaplan-Meier plot restricted to stage I and II patients showed overlapping survival curves for groups I and II. CONCLUSION: Survival during 10-year observation was similar for patients with pulmonary insufficiency treated by wedge resection to that of patients receiving standard resection in this single-institution consecutive cohort.",
author = "Griffin, {John P.} and Eastridge, {Charles E.} and Elizabeth Tolley and Pate, {James W.}",
year = "2006",
month = "11",
day = "1",
doi = "10.1097/01243894-200611000-00007",
language = "English (US)",
volume = "1",
pages = "960--964",
journal = "Journal of Thoracic Oncology",
issn = "1556-0864",
publisher = "International Association for the Study of Lung Cancer",
number = "9",

}

TY - JOUR

T1 - Wedge resection for non-small cell lung cancer in patients with pulmonary insufficiency

T2 - Prospective ten-year survival

AU - Griffin, John P.

AU - Eastridge, Charles E.

AU - Tolley, Elizabeth

AU - Pate, James W.

PY - 2006/11/1

Y1 - 2006/11/1

N2 - BACKGROUND: Possibility of curative resection by lobectomy for non-small cell lung cancer is often denied patients with compromised pulmonary reserve. Analysis of survival of such patients treated by wedge resection was compared with that of patients treated by standard resection, with both groups followed for 10 years. DESIGN: A prospective 5-year cohort study. METHODS: From 1988 to 1992, an observational cohort of 127 consecutive resected patients at Memphis VA Medical Center was divided into those receiving lobectomy in 81 cases and pneumonectomy in 15 cases (group I) versus 31 patients with compromised pulmonary reserve (group II), who had complete tumor excision by wedge resection. Preoperative clinical staging was corrected to surgical-pathological staging after demonstration of its superiority. Survival estimates were obtained by Kaplan-Meier method with curves compared by log rank tests, with all-cause mortality calculated from date of surgery. RESULTS: Extent of disease in group I was 58% stage I, 19% stage II, and 23% stage III. In group II, extent of disease was 84% stage I, 3% stage II, and 14% stage III. Group I median survival was 26 months with 30% 5-year survival; for group II, median survival was 30 months and 32%. Kaplan-Meier survival plots showed similar curves in groups I and II. Realizing less extent of disease in group II, another Kaplan-Meier plot restricted to stage I and II patients showed overlapping survival curves for groups I and II. CONCLUSION: Survival during 10-year observation was similar for patients with pulmonary insufficiency treated by wedge resection to that of patients receiving standard resection in this single-institution consecutive cohort.

AB - BACKGROUND: Possibility of curative resection by lobectomy for non-small cell lung cancer is often denied patients with compromised pulmonary reserve. Analysis of survival of such patients treated by wedge resection was compared with that of patients treated by standard resection, with both groups followed for 10 years. DESIGN: A prospective 5-year cohort study. METHODS: From 1988 to 1992, an observational cohort of 127 consecutive resected patients at Memphis VA Medical Center was divided into those receiving lobectomy in 81 cases and pneumonectomy in 15 cases (group I) versus 31 patients with compromised pulmonary reserve (group II), who had complete tumor excision by wedge resection. Preoperative clinical staging was corrected to surgical-pathological staging after demonstration of its superiority. Survival estimates were obtained by Kaplan-Meier method with curves compared by log rank tests, with all-cause mortality calculated from date of surgery. RESULTS: Extent of disease in group I was 58% stage I, 19% stage II, and 23% stage III. In group II, extent of disease was 84% stage I, 3% stage II, and 14% stage III. Group I median survival was 26 months with 30% 5-year survival; for group II, median survival was 30 months and 32%. Kaplan-Meier survival plots showed similar curves in groups I and II. Realizing less extent of disease in group II, another Kaplan-Meier plot restricted to stage I and II patients showed overlapping survival curves for groups I and II. CONCLUSION: Survival during 10-year observation was similar for patients with pulmonary insufficiency treated by wedge resection to that of patients receiving standard resection in this single-institution consecutive cohort.

UR - http://www.scopus.com/inward/record.url?scp=34247869809&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=34247869809&partnerID=8YFLogxK

U2 - 10.1097/01243894-200611000-00007

DO - 10.1097/01243894-200611000-00007

M3 - Article

C2 - 17409979

AN - SCOPUS:34247869809

VL - 1

SP - 960

EP - 964

JO - Journal of Thoracic Oncology

JF - Journal of Thoracic Oncology

SN - 1556-0864

IS - 9

ER -