Weight Gain Mitigation with Topiramate in Mood Disorders

Tonja M. Woods, Samantha F. Eichner, Andrea Franks

Research output: Contribution to journalReview article

11 Citations (Scopus)

Abstract

OBJECTIVE: To review the evidence of weight loss with use of topiramate in patients with mood disorders. DATA SOURCES: Literature search included MEDLINE (1966-December 2003), International Pharmaceutical Abstracts (1970-December 2003), and EMBASE (1980-December 2003). Search terms included topiramate, weight loss, adverse effect, mood disorders, bipolar disorder. DATA SYNTHESIS: Weight gain is a common adverse effect of many agents used to treat mood disorders. Topiramate has been evaiuated in the management of some mood disorders, and weight loss may be a beneficial side effect in these patients. Case reports, letters to the editor, prospective investigations, and retrospective observational studies were reviewed to identify evidence of weight loss with topiramate use in patients with mood disorders. CONCLUSIONS: Current evidence suggests an association between topiramate and weight loss. Based on the limited data, controlled studies need to be conducted to define the role of topiramate in patients with mood disorders who would also benefit from weight reduction.

Original languageEnglish (US)
Pages (from-to)887-891
Number of pages5
JournalAnnals of Pharmacotherapy
Volume38
Issue number5
DOIs
StatePublished - May 1 2004

Fingerprint

Mood Disorders
Weight Gain
Weight Loss
Bipolar Disorder
MEDLINE
Observational Studies
topiramate
Retrospective Studies
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Pharmacology (medical)

Cite this

Weight Gain Mitigation with Topiramate in Mood Disorders. / Woods, Tonja M.; Eichner, Samantha F.; Franks, Andrea.

In: Annals of Pharmacotherapy, Vol. 38, No. 5, 01.05.2004, p. 887-891.

Research output: Contribution to journalReview article

Woods, Tonja M. ; Eichner, Samantha F. ; Franks, Andrea. / Weight Gain Mitigation with Topiramate in Mood Disorders. In: Annals of Pharmacotherapy. 2004 ; Vol. 38, No. 5. pp. 887-891.
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