Weight variability of scored and unscored psychotropic drug tablets split by a uniquely designed tablet splitting device

Robert J. Nolly, Patrick Rodrigues, Laura Thoma

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Tablets of three psychotropic drugs were split using a uniquely designed tablet splitting device, the Tru-Cut Multi-Tablet Cutter, and evaluated for weight variation utilizing criteria based on the United States Pharmacopeia (USP) 〈27〉 Uniformity of Dosage Units Content Uniformity Criteria. Whole tablets of Risperdal 2 mg and 4 mg, Paxil 20 mg and 40 mg, and Zoloft 100 mg were split by a device that positioned tablets in tablet specific disposable trays for splitting. Each half tablet weight was recorded utilizing a digital electronic balance. Weight variability was determined by comparing actual half tablet weight to theoretical half tablet weight and calculation of the relative standard deviation. Results showed half tablets of all drugs met the weight variation criteria resulting in uniform half tablet dosages as defined by the criteria.

Original languageEnglish (US)
Pages (from-to)321-325
Number of pages5
JournalHospital Pharmacy
Volume40
Issue number4
DOIs
StatePublished - Jan 1 2005

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Psychotropic Drugs
Tablets
Weights and Measures
Equipment and Supplies
Sertraline
Paroxetine
Pharmacopoeias

All Science Journal Classification (ASJC) codes

  • Pharmacy
  • Pharmacology
  • Pharmacology (medical)

Cite this

Weight variability of scored and unscored psychotropic drug tablets split by a uniquely designed tablet splitting device. / Nolly, Robert J.; Rodrigues, Patrick; Thoma, Laura.

In: Hospital Pharmacy, Vol. 40, No. 4, 01.01.2005, p. 321-325.

Research output: Contribution to journalReview article

Nolly, Robert J. ; Rodrigues, Patrick ; Thoma, Laura. / Weight variability of scored and unscored psychotropic drug tablets split by a uniquely designed tablet splitting device. In: Hospital Pharmacy. 2005 ; Vol. 40, No. 4. pp. 321-325.
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