Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression.

Kenneth F. Manly, Jintao Wang, Robert Williams

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Heritable differences in transcribed RNA levels can be mapped as quantitative trait loci (QTLs). Transcribed RNA levels are often measured by hybridization to microarrays of oligonucleotide probes, in which each transcript is represented by multiple probes. The use of recombinant inbred lines allows an estimate of the heritability of expression measured by individual probes. This heritability varies greatly. We have tested heritability-weighted averages to define expression of a transcript and found that these allow detection of more QTLs than previously described methods.

Original languageEnglish (US)
JournalGenome Biology
Volume6
Issue number3
StatePublished - Jan 1 2005

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Quantitative Trait Loci
heritability
gene expression
quantitative trait loci
probe
RNA
Gene Expression
Oligonucleotide Probes
oligonucleotide probes
inbred lines
hybridization
detection
methodology

All Science Journal Classification (ASJC) codes

  • Ecology, Evolution, Behavior and Systematics
  • Genetics
  • Cell Biology

Cite this

Weighting by heritability for detection of quantitative trait loci with microarray estimates of gene expression. / Manly, Kenneth F.; Wang, Jintao; Williams, Robert.

In: Genome Biology, Vol. 6, No. 3, 01.01.2005.

Research output: Contribution to journalArticle

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