What do we know about mechanical strain in lung alveoli?

Esra Roan, Christopher Waters

Research output: Contribution to journalReview article

71 Citations (Scopus)

Abstract

The pulmonary alveolus, terminal gas-exchange unit of the lung, is composed of alveolar epithelial and endothelial cells separated by a thin basement membrane and interstitial space. These cells participate in the maintenance of a delicate system regulated not only by biological factors but also by the mechanical environment of the lung, which undergoes dynamic deformation during breathing. Clinical and animal studies as well as cell culture studies point toward a strong influence of mechanical forces on lung cells and tissues including effects on growth and repair, surfactant release, injury, and inflammation. However, despite substantial advances in our understanding of lung mechanics over the last half century, there are still many unanswered questions regarding the micromechanics of the alveolus and how it deforms during lung inflation. Therefore, the aims of this review are to draw a multidisciplinary account of the mechanics of the alveolus on the basis of its structure, biology, and chemistry and to compare estimates of alveolar deformation from previous studies.

Original languageEnglish (US)
JournalAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Volume301
Issue number5
DOIs
StatePublished - Nov 1 2011

Fingerprint

Lung
Mechanics
Pulmonary Alveoli
Alveolar Epithelial Cells
Economic Inflation
Biological Factors
Basement Membrane
Surface-Active Agents
Respiration
Endothelial Cells
Cell Culture Techniques
Gases
Maintenance
Inflammation
Wounds and Injuries
Growth

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pulmonary and Respiratory Medicine
  • Physiology (medical)
  • Cell Biology

Cite this

What do we know about mechanical strain in lung alveoli? / Roan, Esra; Waters, Christopher.

In: American Journal of Physiology - Lung Cellular and Molecular Physiology, Vol. 301, No. 5, 01.11.2011.

Research output: Contribution to journalReview article

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