Which eligible breast conservation patients choose mastectomy in the setting of newly diagnosed breast cancer?

Cameron D. Adkisson, Sanjay P. Bagaria, Alexander S. Parker, Jillian Lloyd, Tammeza Gibson, Colleen S. Thomas, Michael G. Heckman, Sarah A. McLaughlin

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Purpose. Breast conserving therapy (BCT) and mastectomy offer equivalent survival for women with newly diagnosed breast cancer (BrCa). Despite this, many women eligible for BCT elect mastectomy. Herein, we identify factors associated with choosing ipsilateral mastectomy instead of BCT when mastectomy is not required. Methods. Between July 2007 and June 2010, 520 women with BrCa were treated by a single surgeon who prospectively documented patient eligibility for BCT. For patients who did not require mastectomy (n = 392), we evaluated associations between treatment choice and potential predictors using odds ratios (ORs) obtained from multivariable logistic regression models. P values ≤0.0029 were significant after correction for multiple testing. Results. Of 392 women eligible for BCT, 106 (27%) chose mastectomy and 286 (73%) chose BCT. Multivariate analysis found an increased likelihood of electing mastectomy over BCT for patients with no comorbidities (OR 5.4; P < 0.001) and those with previous mastectomy (OR 23.2; P < 0.001). MRI and biopsy findings were associated with treatment choice because patients who had a second-site biopsy positive for cancer in the same quadrant as the index tumor were more likely to elect mastectomy compared with patients with no additional MRI abnormalities (OR 4.3; P = 0.0027). No association existed on multivariate analysis between choice of mastectomy and patient age, family history, or tumor stage. Conclusions. One in four eligible BCT patients chooses mastectomy. Factors independently associated with choosing mastectomy over BCT include findings of second-site biopsy, previous mastectomy, and absence of comorbidities but not primary tumor characteristics. Further study into a patient's choice for mastectomy is warranted.

Original languageEnglish (US)
Pages (from-to)1129-1136
Number of pages8
JournalAnnals of Surgical Oncology
Volume19
Issue number4
DOIs
StatePublished - Apr 1 2012
Externally publishedYes

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Mastectomy
Breast
Breast Neoplasms
Odds Ratio
Therapeutics
Biopsy
Comorbidity
Neoplasms
Multivariate Analysis
Logistic Models

All Science Journal Classification (ASJC) codes

  • Surgery
  • Oncology

Cite this

Adkisson, C. D., Bagaria, S. P., Parker, A. S., Lloyd, J., Gibson, T., Thomas, C. S., ... McLaughlin, S. A. (2012). Which eligible breast conservation patients choose mastectomy in the setting of newly diagnosed breast cancer? Annals of Surgical Oncology, 19(4), 1129-1136. https://doi.org/10.1245/s10434-011-2080-x

Which eligible breast conservation patients choose mastectomy in the setting of newly diagnosed breast cancer? / Adkisson, Cameron D.; Bagaria, Sanjay P.; Parker, Alexander S.; Lloyd, Jillian; Gibson, Tammeza; Thomas, Colleen S.; Heckman, Michael G.; McLaughlin, Sarah A.

In: Annals of Surgical Oncology, Vol. 19, No. 4, 01.04.2012, p. 1129-1136.

Research output: Contribution to journalArticle

Adkisson, CD, Bagaria, SP, Parker, AS, Lloyd, J, Gibson, T, Thomas, CS, Heckman, MG & McLaughlin, SA 2012, 'Which eligible breast conservation patients choose mastectomy in the setting of newly diagnosed breast cancer?', Annals of Surgical Oncology, vol. 19, no. 4, pp. 1129-1136. https://doi.org/10.1245/s10434-011-2080-x
Adkisson, Cameron D. ; Bagaria, Sanjay P. ; Parker, Alexander S. ; Lloyd, Jillian ; Gibson, Tammeza ; Thomas, Colleen S. ; Heckman, Michael G. ; McLaughlin, Sarah A. / Which eligible breast conservation patients choose mastectomy in the setting of newly diagnosed breast cancer?. In: Annals of Surgical Oncology. 2012 ; Vol. 19, No. 4. pp. 1129-1136.
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abstract = "Purpose. Breast conserving therapy (BCT) and mastectomy offer equivalent survival for women with newly diagnosed breast cancer (BrCa). Despite this, many women eligible for BCT elect mastectomy. Herein, we identify factors associated with choosing ipsilateral mastectomy instead of BCT when mastectomy is not required. Methods. Between July 2007 and June 2010, 520 women with BrCa were treated by a single surgeon who prospectively documented patient eligibility for BCT. For patients who did not require mastectomy (n = 392), we evaluated associations between treatment choice and potential predictors using odds ratios (ORs) obtained from multivariable logistic regression models. P values ≤0.0029 were significant after correction for multiple testing. Results. Of 392 women eligible for BCT, 106 (27{\%}) chose mastectomy and 286 (73{\%}) chose BCT. Multivariate analysis found an increased likelihood of electing mastectomy over BCT for patients with no comorbidities (OR 5.4; P < 0.001) and those with previous mastectomy (OR 23.2; P < 0.001). MRI and biopsy findings were associated with treatment choice because patients who had a second-site biopsy positive for cancer in the same quadrant as the index tumor were more likely to elect mastectomy compared with patients with no additional MRI abnormalities (OR 4.3; P = 0.0027). No association existed on multivariate analysis between choice of mastectomy and patient age, family history, or tumor stage. Conclusions. One in four eligible BCT patients chooses mastectomy. Factors independently associated with choosing mastectomy over BCT include findings of second-site biopsy, previous mastectomy, and absence of comorbidities but not primary tumor characteristics. Further study into a patient's choice for mastectomy is warranted.",
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AU - Bagaria, Sanjay P.

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AU - Lloyd, Jillian

AU - Gibson, Tammeza

AU - Thomas, Colleen S.

AU - Heckman, Michael G.

AU - McLaughlin, Sarah A.

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N2 - Purpose. Breast conserving therapy (BCT) and mastectomy offer equivalent survival for women with newly diagnosed breast cancer (BrCa). Despite this, many women eligible for BCT elect mastectomy. Herein, we identify factors associated with choosing ipsilateral mastectomy instead of BCT when mastectomy is not required. Methods. Between July 2007 and June 2010, 520 women with BrCa were treated by a single surgeon who prospectively documented patient eligibility for BCT. For patients who did not require mastectomy (n = 392), we evaluated associations between treatment choice and potential predictors using odds ratios (ORs) obtained from multivariable logistic regression models. P values ≤0.0029 were significant after correction for multiple testing. Results. Of 392 women eligible for BCT, 106 (27%) chose mastectomy and 286 (73%) chose BCT. Multivariate analysis found an increased likelihood of electing mastectomy over BCT for patients with no comorbidities (OR 5.4; P < 0.001) and those with previous mastectomy (OR 23.2; P < 0.001). MRI and biopsy findings were associated with treatment choice because patients who had a second-site biopsy positive for cancer in the same quadrant as the index tumor were more likely to elect mastectomy compared with patients with no additional MRI abnormalities (OR 4.3; P = 0.0027). No association existed on multivariate analysis between choice of mastectomy and patient age, family history, or tumor stage. Conclusions. One in four eligible BCT patients chooses mastectomy. Factors independently associated with choosing mastectomy over BCT include findings of second-site biopsy, previous mastectomy, and absence of comorbidities but not primary tumor characteristics. Further study into a patient's choice for mastectomy is warranted.

AB - Purpose. Breast conserving therapy (BCT) and mastectomy offer equivalent survival for women with newly diagnosed breast cancer (BrCa). Despite this, many women eligible for BCT elect mastectomy. Herein, we identify factors associated with choosing ipsilateral mastectomy instead of BCT when mastectomy is not required. Methods. Between July 2007 and June 2010, 520 women with BrCa were treated by a single surgeon who prospectively documented patient eligibility for BCT. For patients who did not require mastectomy (n = 392), we evaluated associations between treatment choice and potential predictors using odds ratios (ORs) obtained from multivariable logistic regression models. P values ≤0.0029 were significant after correction for multiple testing. Results. Of 392 women eligible for BCT, 106 (27%) chose mastectomy and 286 (73%) chose BCT. Multivariate analysis found an increased likelihood of electing mastectomy over BCT for patients with no comorbidities (OR 5.4; P < 0.001) and those with previous mastectomy (OR 23.2; P < 0.001). MRI and biopsy findings were associated with treatment choice because patients who had a second-site biopsy positive for cancer in the same quadrant as the index tumor were more likely to elect mastectomy compared with patients with no additional MRI abnormalities (OR 4.3; P = 0.0027). No association existed on multivariate analysis between choice of mastectomy and patient age, family history, or tumor stage. Conclusions. One in four eligible BCT patients chooses mastectomy. Factors independently associated with choosing mastectomy over BCT include findings of second-site biopsy, previous mastectomy, and absence of comorbidities but not primary tumor characteristics. Further study into a patient's choice for mastectomy is warranted.

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