Whisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration

J. Ito, S. Roy, Yu Liu, Y. Cao, Max Fletcher, Lu Lu, John Boughter, S. Grün, Detlef Heck

Research output: Contribution to journalArticle

48 Citations (Scopus)

Abstract

Current evidence suggests that delta oscillations (0.5-4â ‰Hz) in the brain are generated by intrinsic network mechanisms involving cortical and thalamic circuits. Here we report that delta band oscillation in spike and local field potential (LFP) activity in the whisker barrel cortex of awake mice is phase locked to respiration. Furthermore, LFP oscillations in the gamma frequency band (30-80â ‰Hz) are amplitude modulated in phase with the respiratory rhythm. Removal of the olfactory bulb eliminates respiration-locked delta oscillations and delta-gamma phase-amplitude coupling. Our findings thus suggest respiration-locked olfactory bulb activity as a main driving force behind delta oscillations and gamma power modulation in the whisker barrel cortex in the awake state.

Original languageEnglish (US)
Article number3572
JournalNature Communications
Volume5
DOIs
StatePublished - Apr 1 2014

Fingerprint

Vibrissae
cortexes
respiration
Frequency bands
mice
Brain
Respiration
Olfactory Bulb
Modulation
oscillations
Networks (circuits)
bulbs
potential fields
rhythm
spikes
brain
modulation

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

Cite this

Whisker barrel cortex delta oscillations and gamma power in the awake mouse are linked to respiration. / Ito, J.; Roy, S.; Liu, Yu; Cao, Y.; Fletcher, Max; Lu, Lu; Boughter, John; Grün, S.; Heck, Detlef.

In: Nature Communications, Vol. 5, 3572, 01.04.2014.

Research output: Contribution to journalArticle

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AU - Lu, Lu

AU - Boughter, John

AU - Grün, S.

AU - Heck, Detlef

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