White Blood Cell Count and Mortality in the Baltimore Longitudinal Study of Aging

Carmelinda Ruggiero, E. Metter, Antonio Cherubini, Marcello Maggio, Ranjan Sen, Samer S. Najjar, Gwen B. Windham, Alessandro Ble, Umberto Senin, Luigi Ferrucci

Research output: Contribution to journalArticle

95 Citations (Scopus)

Abstract

Objectives: We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002. Background: The WBC count is a clinical marker of inflammation and a strong predictor of mortality. Limited data exist on the WBC count secular trend and the relationship between WBC and mortality. Methods: One thousand eighty-three women and 1,720 men were evaluated longitudinally in the Baltimore Longitudinal Study of Aging. Blood samples and medical information were collected at the study entry and every 2 years during follow-up visits. The WBC count and all-cause, cardiovascular, and cancer mortality were assessed. Results: A downward trend in WBC count was observed from 1958 to 2002. The secular downward trend was independent of age, gender, race, smoking, body mass index, and physical activity. The WBC count was nonlinearly associated with all-cause mortality and almost linearly associated with cardiovascular mortality. Participants with baseline WBC <3,500 cells/mm3 and WBC >6,000 cells/mm3 had higher mortality than those with 3,500 to 6,000 WBC/mm3. Within each WBC group, age-adjusted mortality rates declined in successive cohorts from the 1960s to the 1990s. Participants who died had higher WBC than those who survived, and the difference was statistically significant within 5 years before death. Conclusions: Our study provides evidence for a secular downward trend in WBC count over the period from 1958 to 2002. Higher WBC counts are associated with higher mortality in successive cohorts. We found no evidence that the decline of age-specific mortality rates that occurred from 1960 to 2000 was attributable to a secular downward trend in WBC.

Original languageEnglish (US)
Pages (from-to)1841-1850
Number of pages10
JournalJournal of the American College of Cardiology
Volume49
Issue number18
DOIs
StatePublished - May 8 2007
Externally publishedYes

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Baltimore
Leukocyte Count
Longitudinal Studies
Mortality
Leukocytes
Blood Group Antigens
Body Mass Index
Biomarkers
Smoking
Exercise
Inflammation

All Science Journal Classification (ASJC) codes

  • Nursing(all)

Cite this

White Blood Cell Count and Mortality in the Baltimore Longitudinal Study of Aging. / Ruggiero, Carmelinda; Metter, E.; Cherubini, Antonio; Maggio, Marcello; Sen, Ranjan; Najjar, Samer S.; Windham, Gwen B.; Ble, Alessandro; Senin, Umberto; Ferrucci, Luigi.

In: Journal of the American College of Cardiology, Vol. 49, No. 18, 08.05.2007, p. 1841-1850.

Research output: Contribution to journalArticle

Ruggiero, C, Metter, E, Cherubini, A, Maggio, M, Sen, R, Najjar, SS, Windham, GB, Ble, A, Senin, U & Ferrucci, L 2007, 'White Blood Cell Count and Mortality in the Baltimore Longitudinal Study of Aging', Journal of the American College of Cardiology, vol. 49, no. 18, pp. 1841-1850. https://doi.org/10.1016/j.jacc.2007.01.076
Ruggiero, Carmelinda ; Metter, E. ; Cherubini, Antonio ; Maggio, Marcello ; Sen, Ranjan ; Najjar, Samer S. ; Windham, Gwen B. ; Ble, Alessandro ; Senin, Umberto ; Ferrucci, Luigi. / White Blood Cell Count and Mortality in the Baltimore Longitudinal Study of Aging. In: Journal of the American College of Cardiology. 2007 ; Vol. 49, No. 18. pp. 1841-1850.
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abstract = "Objectives: We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002. Background: The WBC count is a clinical marker of inflammation and a strong predictor of mortality. Limited data exist on the WBC count secular trend and the relationship between WBC and mortality. Methods: One thousand eighty-three women and 1,720 men were evaluated longitudinally in the Baltimore Longitudinal Study of Aging. Blood samples and medical information were collected at the study entry and every 2 years during follow-up visits. The WBC count and all-cause, cardiovascular, and cancer mortality were assessed. Results: A downward trend in WBC count was observed from 1958 to 2002. The secular downward trend was independent of age, gender, race, smoking, body mass index, and physical activity. The WBC count was nonlinearly associated with all-cause mortality and almost linearly associated with cardiovascular mortality. Participants with baseline WBC <3,500 cells/mm3 and WBC >6,000 cells/mm3 had higher mortality than those with 3,500 to 6,000 WBC/mm3. Within each WBC group, age-adjusted mortality rates declined in successive cohorts from the 1960s to the 1990s. Participants who died had higher WBC than those who survived, and the difference was statistically significant within 5 years before death. Conclusions: Our study provides evidence for a secular downward trend in WBC count over the period from 1958 to 2002. Higher WBC counts are associated with higher mortality in successive cohorts. We found no evidence that the decline of age-specific mortality rates that occurred from 1960 to 2000 was attributable to a secular downward trend in WBC.",
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AU - Maggio, Marcello

AU - Sen, Ranjan

AU - Najjar, Samer S.

AU - Windham, Gwen B.

AU - Ble, Alessandro

AU - Senin, Umberto

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