Why Is Reverse Takotsubo "Reverse"?

Daniela Rosu, Sameh Askandar, Rami Khouzam

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

OBJECTIVES: Takotsubo cardiomyopathy (TTC) is an acute cardiac syndrome simulating myocardial infarction that is characterized by transient wall motion abnormalities in the absence of coronary artery obstruction. Reverse TTC (rTTC) is a recently described variant of TTC. This review defines and compares both forms of TTC, stating their resemblances and differences.

METHODS: We conducted a search of the MEDLINE database. Forty-one cases of rTTC met our eligibility criteria and were summarized in a synthesis of the demographic features, clinical characteristics, and laboratory studies.

RESULTS: Of the 41 patients studied, 73% were women. Patients' ages ranged from 19 to 69 years and the mean age was 43. The predominant electrocardiogram finding was ST-segment depression, whereas ST-segment elevation was present in only 6 patients (14.5%). Troponin levels were raised in 92.6% of the patients, with a mean troponin I of 7.7 ng/mL. All of the patients had wall motion abnormalities on echocardiography and the mean ejection fraction was 29.3%. Of the 27 patients (66%) who had a documented angiography, 22 (81.5%) had normal coronaries and 5 (18.5%) had minor or mild obstructive coronary artery disease. Of the 41 patients, 9 (22%) died, and the mean recovery time of the ejection fraction in the survivors was 16 days.

CONCLUSIONS: rTTC is a distinct presentation from the classic TTC. Remarkable differences exist between both forms in terms of mean age, sex, electrocardiogram presentation, troponin levels, and mortality.

Original languageEnglish (US)
Pages (from-to)381-385
Number of pages5
JournalSouthern Medical Journal
Volume110
Issue number5
DOIs
StatePublished - May 1 2017
Externally publishedYes

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Takotsubo Cardiomyopathy
Troponin
Electrocardiography
Troponin I
MEDLINE
Survivors
Echocardiography
Coronary Artery Disease
Coronary Vessels
Angiography
Myocardial Infarction
Demography
Databases
Mortality

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Why Is Reverse Takotsubo "Reverse"? / Rosu, Daniela; Askandar, Sameh; Khouzam, Rami.

In: Southern Medical Journal, Vol. 110, No. 5, 01.05.2017, p. 381-385.

Research output: Contribution to journalReview article

Rosu, Daniela ; Askandar, Sameh ; Khouzam, Rami. / Why Is Reverse Takotsubo "Reverse"?. In: Southern Medical Journal. 2017 ; Vol. 110, No. 5. pp. 381-385.
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