Workshop on diagnosis and treatment of cardiac maladaptive remodeling

Karl Weber, Willa A. Hsueh, John T. Watson, Stephen S. Goldman

Research output: Contribution to journalArticle

Abstract

Heart failure is a major health problem. Accordingly, its pathophysiologic basis and pathogenic origins have received considerable research interest. To date much attention has focused on the importance of cardiac myocyte dysfunction and the adaptations of this muscular compartment as root causes of heart failure. Equally compelling to its origins, albeit less well recognized and understudied, is a role for the cardiac interstitium and its extracellular matrix. This dynamic compartment includes pluripotent fibroblasts with considerable phenotypic and functional diversity and a microenvironment composed of signaling molecules that regulate tissue homeostasis, including cell growth and behavior. Matrix remodeling provides a structural basis for ventricular diastolic and/or systolic dysfunction. This brief summary report overviews discussions held at an NHLBI-sponsored workshop focused on matrix remodeling in heart failure. Its purpose was to examine this remodeling process, not only for a better understanding of heart failure, but also to evaluate whether it would be a ripe target for preventive and therapeutic interventions.

Original languageEnglish (US)
Pages (from-to)97-100
Number of pages4
JournalHeart Failure Reviews
Volume4
Issue number1
DOIs
StatePublished - Sep 29 1999
Externally publishedYes

Fingerprint

Heart Failure
Education
National Heart, Lung, and Blood Institute (U.S.)
Cardiac Myocytes
Extracellular Matrix
Homeostasis
Fibroblasts
Health
Growth
Research
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Workshop on diagnosis and treatment of cardiac maladaptive remodeling. / Weber, Karl; Hsueh, Willa A.; Watson, John T.; Goldman, Stephen S.

In: Heart Failure Reviews, Vol. 4, No. 1, 29.09.1999, p. 97-100.

Research output: Contribution to journalArticle

Weber, Karl ; Hsueh, Willa A. ; Watson, John T. ; Goldman, Stephen S. / Workshop on diagnosis and treatment of cardiac maladaptive remodeling. In: Heart Failure Reviews. 1999 ; Vol. 4, No. 1. pp. 97-100.
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