Wound healing following myocardial infarction

Karl Weber, Yao Sun, Laxmansa C. Katwa

Research output: Contribution to journalReview article

47 Citations (Scopus)

Abstract

A wound-healing response that eventuates in fibrous tissue formation appears at the site of myocardial infarction (Ml) in the affected ventricle. Fibrosis can likewise appear remote to the M I and cause an extensive structural remodeling of the myocardium of infarcted and noninfarcted ventricles. Substances involved in promoting healing at and remote to M I are of considerable interest and an important clinical issue, given that the healing response is subject to pharmacologic intervention. Angiotensin- converting enzyme (ACE) is expressed by wound-healing fibroblast like cells; it likely serves to regulate local concentrations of angiotensin II and bradykinin involved in healing and matrix remodeling. Wound healing following MI and its regulation are addressed in this review.

Original languageEnglish (US)
Pages (from-to)447-455
Number of pages9
JournalClinical Cardiology
Volume19
Issue number6
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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Wound Healing
Myocardial Infarction
Bradykinin
Peptidyl-Dipeptidase A
Angiotensin II
Myocardium
Fibrosis
Fibroblasts

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Wound healing following myocardial infarction. / Weber, Karl; Sun, Yao; Katwa, Laxmansa C.

In: Clinical Cardiology, Vol. 19, No. 6, 01.01.1996, p. 447-455.

Research output: Contribution to journalReview article

Weber, Karl ; Sun, Yao ; Katwa, Laxmansa C. / Wound healing following myocardial infarction. In: Clinical Cardiology. 1996 ; Vol. 19, No. 6. pp. 447-455.
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