Wound healing following myocardial infarction in the rat

Role for bradykinin and prostaglandins

Clovis de Carvalho Frimm, Yao Sun, Karl Weber

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Bradykinin and prostaglandins are established mediators of exudative and inflammatory phases of healing. Their contribution to the fibrogenic component of healing in the heart is less certain. We therefore undertook the present study in rats with acute myocardial infarction (MI) following left coronary artery ligation. Treatment with a bradykinin B2 receptor antagonist (Hoel40, 0.5 μg/kg/min s.c.) or a cyclooxygenase inhibitor (indomethacin, 2 mg/kg p.o.), initiated 24 h after surgery, was examined for responses in MI topography (size and area), MI and nonMI tissue fibrosis (fibrillar collagen specific picrosirius red). Early (week 1) and late (week 4) phases of fibrogenesis postMI were examined. Compared to control, we found: (1) MI size at weeks 1 and 4 was comparable in untreated and treated rats; (2) infarct area, a measure of scar thickness, was reduced (P < 0.05) at week 4 by each intervention; and (3) densitometric collagen volume fraction did not reveal a reduction in collagen accumulation at the MI site, but this was evident remote to the MI (P < 0.05) at week 4 for each agent. Thus, pharmacological interference with bradykinin-receptor binding or prostaglandin synthesis following MI is associated with reduced fibrillar collagen formation. Though the mechanism responsible for observed alteration in fibrogenesis is uncertain, anti-inflammatory and anti-proliferative properties of these agents may be responsible.

Original languageEnglish (US)
Pages (from-to)1279-1285
Number of pages7
JournalJournal of Molecular and Cellular Cardiology
Volume28
Issue number6
DOIs
StatePublished - Jan 1 1996
Externally publishedYes

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Bradykinin
Wound Healing
Prostaglandins
Myocardial Infarction
Fibrillar Collagens
Collagen
Bradykinin Receptors
Cyclooxygenase 2 Inhibitors
Indomethacin
Cicatrix
Ligation
Coronary Vessels
Fibrosis
Anti-Inflammatory Agents
Pharmacology

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cardiology and Cardiovascular Medicine

Cite this

Wound healing following myocardial infarction in the rat : Role for bradykinin and prostaglandins. / Frimm, Clovis de Carvalho; Sun, Yao; Weber, Karl.

In: Journal of Molecular and Cellular Cardiology, Vol. 28, No. 6, 01.01.1996, p. 1279-1285.

Research output: Contribution to journalArticle

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