WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory

Benjamin R. Carlson, Krissey E. Lloyd, Allison Kruszewski, Il Hwan Kim, Ramona M. Rodriguiz, Clifford Heindel, Marika Faytell, Serena M. Dudek, William C. Wetsel, Scott H. Soderling

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

The WAVE-associated Rac GAP, WRP, is thought to regulate key aspects of synapse development and function and may be linked to mental retardation in humans.WRPcontains a newly described inverse F-BAR (IF-BAR) domain of unknown function. Our studies show that this domain senses/facilitates outward protrusions analogous to filopodia and that the molecular basis for this is likely explained by a convex lipid-binding surface on the WRPIF-BAR domain. In dendrites the IF-BAR domain of WRP forms a bud on the shaft from which precursors to spines emerge. Loss of WRP in vivo and in vitro results in reduced density of spines. In vivo this is primarily a loss of mushroom-shaped spines. Developmentally, WRP function is critical at the onset of spinogenesis, when dendritic filopodia are prevalent. Finally, because WRP is implicated in mental retardation, behaviors of WRP heterozygous and null mice have been evaluated. Results from these studies confirm that loss of WRP is linked to impaired learning and memory.

Original languageEnglish (US)
Pages (from-to)2447-2460
Number of pages14
JournalJournal of Neuroscience
Volume31
Issue number7
DOIs
StatePublished - Feb 16 2011

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Long-Term Memory
Pseudopodia
Spine
Intellectual Disability
Agaricales
Dendrites
Synapses
Learning
Lipids

All Science Journal Classification (ASJC) codes

  • Neuroscience(all)

Cite this

WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. / Carlson, Benjamin R.; Lloyd, Krissey E.; Kruszewski, Allison; Kim, Il Hwan; Rodriguiz, Ramona M.; Heindel, Clifford; Faytell, Marika; Dudek, Serena M.; Wetsel, William C.; Soderling, Scott H.

In: Journal of Neuroscience, Vol. 31, No. 7, 16.02.2011, p. 2447-2460.

Research output: Contribution to journalArticle

Carlson, BR, Lloyd, KE, Kruszewski, A, Kim, IH, Rodriguiz, RM, Heindel, C, Faytell, M, Dudek, SM, Wetsel, WC & Soderling, SH 2011, 'WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory', Journal of Neuroscience, vol. 31, no. 7, pp. 2447-2460. https://doi.org/10.1523/JNEUROSCI.4433-10.2011
Carlson, Benjamin R. ; Lloyd, Krissey E. ; Kruszewski, Allison ; Kim, Il Hwan ; Rodriguiz, Ramona M. ; Heindel, Clifford ; Faytell, Marika ; Dudek, Serena M. ; Wetsel, William C. ; Soderling, Scott H. / WRP/srGAP3 facilitates the initiation of spine development by an inverse F-BAR domain, and its loss impairs long-term memory. In: Journal of Neuroscience. 2011 ; Vol. 31, No. 7. pp. 2447-2460.
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